Detalhe da pesquisa
1.
Development of a carbon-14 labeling approach to support disposition studies with a pegylated biologic.
Drug Metab Dispos
; 40(9): 1677-85, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22627466
2.
Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors.
Mol Pharmacol
; 73(2): 338-48, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17975007
3.
7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: design, synthesis, and biological activity.
Bioorg Med Chem Lett
; 18(18): 5130-3, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18718756
4.
4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors.
Bioorg Med Chem Lett
; 18(16): 4615-9, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18653333
5.
A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity: design, synthesis, and biological activity.
Bioorg Med Chem Lett
; 18(17): 4896-9, 2008 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18678484
6.
Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases.
Bioorg Med Chem Lett
; 18(12): 3495-9, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18508264
7.
1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities.
J Med Chem
; 48(13): 4208-11, 2005 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15974571
8.
Discovery of potent heterodimeric antagonists of inhibitor of apoptosis proteins (IAPs) with sustained antitumor activity.
J Med Chem
; 58(3): 1556-62, 2015 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25584393
9.
The discovery of macrocyclic XIAP antagonists from a DNA-programmed chemistry library, and their optimization to give lead compounds with in vivo antitumor activity.
J Med Chem
; 58(6): 2855-61, 2015 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25695766
10.
Structures of adnectin/protein complexes reveal an expanded binding footprint.
Structure
; 20(2): 259-69, 2012 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22325775
11.
A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor.
MAbs
; 3(1): 38-48, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21099371
12.
Synthesis of 3-(1H-benzimidazol-2-yl)-5-isoquinolin-4-ylpyrazolo[1,2-b]pyridine, a potent cyclin dependent kinase 1 (CDK1) inhibitor.
Bioorg Med Chem Lett
; 17(5): 1243-5, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17234412
13.
Design, synthesis, and evaluation of 3,4-disubstituted pyrazole analogues as anti-tumor CDK inhibitors.
Bioorg Med Chem Lett
; 17(16): 4557-61, 2007 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17574416
14.
4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: synthesis and biological evaluation.
Bioorg Med Chem Lett
; 17(12): 3266-70, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17481894
15.
Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents.
Bioorg Med Chem Lett
; 17(15): 4297-302, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17532631
16.
Synthesis and biological study of 4-aminopyrimidine-5-carboxaldehyde oximes as antiproliferative VEGFR-2 inhibitors.
Bioorg Med Chem Lett
; 16(23): 6063-6, 2006 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16979339
17.
3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.
Bioorg Med Chem Lett
; 15(9): 2221-4, 2005 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15837297