Detalhe da pesquisa
1.
Synthesis and evaluation of novel N1-acylated 5-(4-pyridinyl)indazole derivatives as potent and selective haspin inhibitors.
Bioorg Chem
; 145: 107235, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38447464
2.
N1 -Benzoylated 5-(4-pyridinyl)indazole-based kinase inhibitors: Attaining haspin and Clk4 selectivity via modulation of the benzoyl substituents.
Arch Pharm (Weinheim)
; : e2400020, 2024 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38478964
3.
Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents.
Arch Pharm (Weinheim)
; 357(4): e2300656, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38304944
4.
An overview of cdc2-like kinase 1 (Clk1) inhibitors and their therapeutic indications.
Med Res Rev
; 43(2): 343-398, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36262046
5.
Targeting the binding pocket of the fluorophore 8-anilinonaphthalene-1-sulfonic acid in the bacterial enzyme MurA.
Arch Pharm (Weinheim)
; 356(9): e2300237, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37464574
6.
Nanoparticle Fraught Liposomes: A Platform for Increased Antibiotic Selectivity in Multidrug Resistant Bacteria.
Mol Pharm
; 19(9): 3163-3177, 2022 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35876358
7.
Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part.
Bioorg Med Chem Lett
; 59: 128531, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35007723
8.
From EGFR kinase inhibitors to anti-inflammatory drugs: Optimization and biological evaluation of (4-(phenylamino)quinazolinyl)-phenylthiourea derivatives as novel NF-κB inhibitors.
Bioorg Chem
; 127: 105977, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35779404
9.
Synthesis, biological evaluation and molecular docking studies of indeno [1, 2-c] pyrazol derivatives as inhibitors of mitochondrial malate dehydrogenase 2 (MDH2).
Bioorg Chem
; 110: 104779, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33689977
10.
Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Optimization of the 2,4-substituents.
Bioorg Chem
; 117: 105422, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34700110
11.
5-Methoxybenzothiophene-2-Carboxamides as Inhibitors of Clk1/4: Optimization of Selectivity and Cellular Potency.
Molecules
; 26(4)2021 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33668683
12.
Acetaminophen-induced liver injury is mediated by the ion channel TRPV4.
FASEB J
; 33(9): 10257-10268, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31207191
13.
Synthesis of novel 1,2-diarylpyrazolidin-3-one-based compounds and their evaluation as broad spectrum antibacterial agents.
Bioorg Chem
; 99: 103759, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32220665
14.
Discovery of trisubstituted pyrazolines as a novel scaffold for the development of selective phosphodiesterase 5 inhibitors.
Bioorg Chem
; 104: 104322, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33142429
15.
Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitors.
Bioorg Chem
; 98: 103742, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32199305
16.
Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling.
EMBO J
; 31(19): 3795-808, 2012 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22850668
17.
Synthesis and Optimization of New 3,6-Disubstitutedindole Derivatives and Their Evaluation as Anticancer Agents Targeting the MDM2/MDMx Complex.
Chem Pharm Bull (Tokyo)
; 64(1): 34-41, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26726742
18.
Multispectral Optoacoustic Tomography for Assessment of Crohn's Disease Activity.
N Engl J Med
; 376(13): 1292-1294, 2017 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-28355498
19.
Screening Dyrk1A inhibitors by MALDI-QqQ mass spectrometry: systematic comparison to established radiometric, luminescence, and LC-UV-MS assays.
Anal Bioanal Chem
; 406(12): 2841-52, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24618988
20.
New CYP17 hydroxylase inhibitors: synthesis, biological evaluation, QSAR, and molecular docking study of new pregnenolone analogs.
Arch Pharm (Weinheim)
; 347(12): 896-907, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25251696