Pesquisa | Portal de Pesquisa da BVS

1.

Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia.

Liang, Kaiwei; Volk, Andrew G; Haug, Jeffrey S; Marshall, Stacy A; Woodfin, Ashley R; Bartom, Elizabeth T; Gilmore, Joshua M; Florens, Laurence; Washburn, Michael P; Sullivan, Kelly D; Espinosa, Joaquin M; Cannova, Joseph; Zhang, Jiwang; Smith, Edwin R; Crispino, John D; Shilatifard, Ali.

Cell ; 168(1-2): 59-72.e13, 2017 Jan 12.

Artigo em Inglês | MEDLINE | ID: mdl-28065413

2.

HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.

Galbraith, Matthew D; Allen, Mary A; Bensard, Claire L; Wang, Xiaoxing; Schwinn, Marie K; Qin, Bo; Long, Henry W; Daniels, Danette L; Hahn, William C; Dowell, Robin D; Espinosa, Joaquín M.

Cell ; 153(6): 1327-39, 2013 Jun 06.

Artigo em Inglês | MEDLINE | ID: mdl-23746844

3.

Transcriptional Responses to IFN-Î³ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions.

Steinparzer, Iris; Sedlyarov, Vitaly; Rubin, Jonathan D; Eislmayr, Kevin; Galbraith, Matthew D; Levandowski, Cecilia B; Vcelkova, Terezia; Sneezum, Lucy; Wascher, Florian; Amman, Fabian; Kleinova, Renata; Bender, Heather; Andrysik, Zdenek; Espinosa, Joaquin M; Superti-Furga, Giulio; Dowell, Robin D; Taatjes, Dylan J; Kovarik, Pavel.

Mol Cell ; 76(3): 485-499.e8, 2019 11 07.

Artigo em Inglês | MEDLINE | ID: mdl-31495563

4.

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.

Zhong, Lei; D'Urso, Agustina; Toiber, Debra; Sebastian, Carlos; Henry, Ryan E; Vadysirisack, Douangsone D; Guimaraes, Alexander; Marinelli, Brett; Wikstrom, Jakob D; Nir, Tomer; Clish, Clary B; Vaitheesvaran, Bhavapriya; Iliopoulos, Othon; Kurland, Irwin; Dor, Yuval; Weissleder, Ralph; Shirihai, Orian S; Ellisen, Leif W; Espinosa, Joaquin M; Mostoslavsky, Raul.

Cell ; 140(2): 280-93, 2010 Jan 22.

Artigo em Inglês | MEDLINE | ID: mdl-20141841

5.

Specialized interferon action in COVID-19.

Galbraith, Matthew D; Kinning, Kohl T; Sullivan, Kelly D; Araya, Paula; Smith, Keith P; Granrath, Ross E; Shaw, Jessica R; Baxter, Ryan; Jordan, Kimberly R; Russell, Seth; Dzieciatkowska, Monika; Reisz, Julie A; Gamboni, Fabia; Cendali, Francesca; Ghosh, Tusharkanti; Guo, Kejun; Wilson, Cara C; Santiago, Mario L; Monte, Andrew A; Bennett, Tellen D; Hansen, Kirk C; Hsieh, Elena W Y; D'Alessandro, Angelo; Espinosa, Joaquin M.

Proc Natl Acad Sci U S A ; 119(11)2022 03 15.

Artigo em Inglês | MEDLINE | ID: mdl-35217532

6.

Revisiting lncRNAs: How Do You Know Yours Is Not an eRNA?

Espinosa, Joaquín M.

Mol Cell ; 62(1): 1-2, 2016 Apr 07.

Artigo em Inglês | MEDLINE | ID: mdl-27058782

7.

Metabolic signatures of cardiorenal dysfunction in plasma from sickle cell patients as a function of therapeutic transfusion and hydroxyurea treatment.

D'Alessandro, Angelo; Nouraie, S Mehdi; Zhang, Yingze; Cendali, Francesca; Gamboni, Fabia; Reisz, Julie A; Zhang, Xu; Bartsch, Kyle W; Galbraith, Matthew D; Espinosa, Joaquin M; Gordeuk, Victor R; Gladwin, Mark T.

Haematologica ; 108(12): 3418-3432, 2023 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-37439373

8.

Plasma neurofilament light chain concentrations are elevated in youth-onset type 2 diabetes and associated with neuropathy.

Fridman, Vera; Sillau, Stefan; Ritchie, Alanna; Bockhorst, Jacob; Coughlan, Christina; Araya, Paula; Espinosa, Joaquin M; Smith, Keith; Lange, Ethan M; Lange, Leslie A; Ghormli, Laure El; Drews, Kimberly L; Zeitler, Philip; Reusch, Jane E B.

J Peripher Nerv Syst ; 28(3): 460-470, 2023 09.

Artigo em Inglês | MEDLINE | ID: mdl-37341347

9.

Back to bases: how a nucleotide biosynthetic enzyme controls p53 activation.

Guarnieri, Anna L; Espinosa, Joaquín M.

Mol Cell ; 53(3): 365-7, 2014 Feb 06.

Artigo em Inglês | MEDLINE | ID: mdl-24507714

10.

Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity.

Araya, Paula; Waugh, Katherine A; Sullivan, Kelly D; Núñez, Nicolás G; Roselli, Emiliano; Smith, Keith P; Granrath, Ross E; Rachubinski, Angela L; Enriquez Estrada, Belinda; Butcher, Eric T; Minter, Ross; Tuttle, Kathryn D; Bruno, Tullia C; Maccioni, Mariana; Espinosa, Joaquín M.

Proc Natl Acad Sci U S A ; 116(48): 24231-24241, 2019 11 26.

Artigo em Inglês | MEDLINE | ID: mdl-31699819

11.

On the Origin of lncRNAs: Missing Link Found.

Espinosa, Joaquín M.

Trends Genet ; 33(10): 660-662, 2017 10.

Artigo em Inglês | MEDLINE | ID: mdl-28778681

12.

Addressing challenges in health care and research for people with Down syndrome.

Fortea, Juan; McGlinchey, Eimear; Espinosa, Joaquín M; Rafii, Michael S.

Lancet ; 403(10439): 1830-1833, 2024 May 11.

Artigo em Inglês | MEDLINE | ID: mdl-38521088

13.

Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity.

Andrysik, Zdenek; Galbraith, Matthew D; Guarnieri, Anna L; Zaccara, Sara; Sullivan, Kelly D; Pandey, Ahwan; MacBeth, Morgan; Inga, Alberto; Espinosa, Joaquín M.

Genome Res ; 27(10): 1645-1657, 2017 10.

Artigo em Inglês | MEDLINE | ID: mdl-28904012

14.

Get back TFIIF, don't let me Gdown1.

Espinosa, Joaquín M.

Mol Cell ; 45(1): 3-5, 2012 Jan 13.

Artigo em Inglês | MEDLINE | ID: mdl-22244325

15.

Further understanding the connection between Alzheimer's disease and Down syndrome.

Snyder, Heather M; Bain, Lisa J; Brickman, Adam M; Carrillo, Maria C; Esbensen, Anna J; Espinosa, Joaquin M; Fernandez, Fabian; Fortea, Juan; Hartley, Sigan L; Head, Elizabeth; Hendrix, James; Kishnani, Priya S; Lai, Florence; Lao, Patrick; Lemere, Cynthia; Mobley, William; Mufson, Elliott J; Potter, Huntington; Zaman, Shahid H; Granholm, Ann-Charlotte; Rosas, H Diana; Strydom, Andre; Whitten, Michelle Sie; Rafii, Michael S.

Alzheimers Dement ; 16(7): 1065-1077, 2020 07.

Artigo em Inglês | MEDLINE | ID: mdl-32544310

16.

ΔNp63α represses anti-proliferative genes via H2A.Z deposition.

Gallant-Behm, Corrie L; Ramsey, Matthew R; Bensard, Claire L; Nojek, Ignacio; Tran, Jack; Liu, Minghua; Ellisen, Leif W; Espinosa, Joaquín M.

Genes Dev ; 26(20): 2325-36, 2012 Oct 15.

Artigo em Inglês | MEDLINE | ID: mdl-23019126

17.

The meaning of pausing.

Espinosa, Joaquín M.

Mol Cell ; 40(4): 507-8, 2010 Nov 24.

Artigo em Inglês | MEDLINE | ID: mdl-21095581

18.

Differential regulation of p53 target genes: it's (core promoter) elementary.

Gomes, Nathan P; Espinosa, Joaquín M.

Genes Dev ; 24(2): 111-4, 2010 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-20080948

19.

Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding.

Gomes, Nathan P; Espinosa, Joaquín M.

Genes Dev ; 24(10): 1022-34, 2010 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-20478995

20.

A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint.

Beckerman, Rachel; Donner, Aaron J; Mattia, Melissa; Peart, Melissa J; Manley, James L; Espinosa, Joaquin M; Prives, Carol.

Genes Dev ; 23(11): 1364-77, 2009 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-19487575

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Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia.

HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.

Transcriptional Responses to IFN-Î³ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions.

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.

Specialized interferon action in COVID-19.

Revisiting lncRNAs: How Do You Know Yours Is Not an eRNA?

Metabolic signatures of cardiorenal dysfunction in plasma from sickle cell patients as a function of therapeutic transfusion and hydroxyurea treatment.

Plasma neurofilament light chain concentrations are elevated in youth-onset type 2 diabetes and associated with neuropathy.

Back to bases: how a nucleotide biosynthetic enzyme controls p53 activation.

Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity.

On the Origin of lncRNAs: Missing Link Found.

Addressing challenges in health care and research for people with Down syndrome.

Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity.

Get back TFIIF, don't let me Gdown1.

Further understanding the connection between Alzheimer's disease and Down syndrome.

ΔNp63α represses anti-proliferative genes via H2A.Z deposition.

The meaning of pausing.

Differential regulation of p53 target genes: it's (core promoter) elementary.

Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding.

A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint.