Detalhe da pesquisa
1.
Non-Invasive Buccal Swab Gene Testing for Skin Cancer Risk
J Drugs Dermatol
; 18(5): 448-453, 2019 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31141850
2.
Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease.
PLoS Biol
; 12(8): e1001923, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25093460
3.
Optimization of a series of heterocycles as survival motor neuron gene transcription enhancers.
Bioorg Med Chem Lett
; 27(23): 5144-5148, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29103974
4.
A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity.
Hum Mol Genet
; 23(18): 4887-905, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24794857
5.
The Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activity.
J Biol Chem
; 289(19): 13042-53, 2014 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24695735
6.
Dehydro-alpha-lapachone, a plant product with antivascular activity.
Proc Natl Acad Sci U S A
; 108(28): 11596-601, 2011 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21709229
7.
Identification of novel small molecules that elevate Klotho expression.
Biochem J
; 441(1): 453-61, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21939436
8.
Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production.
Hepatology
; 54(2): 664-74, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21538437
9.
Acid ß-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing.
Ann Neurol
; 69(6): 940-53, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21472771
10.
Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors.
Bioorg Med Chem Lett
; 22(5): 2015-9, 2012 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22335895
11.
Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant.
Biochemistry
; 50(43): 9399-408, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21961647
12.
Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators.
Bioorg Med Chem Lett
; 21(19): 5774-7, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21875806
13.
Kinetic mechanistic studies of Cdk5/p25-catalyzed H1P phosphorylation: metal effect and solvent kinetic isotope effect.
Biochemistry
; 49(23): 4921-9, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20491486
14.
Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2: characterization of the kinase and GTPase activities.
Biochemistry
; 49(9): 2008-17, 2010 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-20146535
15.
Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2--discovery of LRRK2 inhibitors.
Anal Biochem
; 404(2): 186-92, 2010 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20566370
16.
Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors.
Bioorg Med Chem Lett
; 20(12): 3491-4, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20836251
17.
Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett
; 19(21): 6122-6, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19783434
18.
Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors.
Biochemistry
; 47(32): 8367-77, 2008 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18636751
19.
Identification of small molecule inhibitors of the mitotic kinase haspin by high-throughput screening using a homogeneous time-resolved fluorescence resonance energy transfer assay.
J Biomol Screen
; 13(10): 1025-34, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18978305
20.
Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening.
Anal Biochem
; 383(1): 85-92, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18762160