Detalhe da pesquisa
1.
Discovery of pyridyl sulfonamide 11-beta-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors for the treatment of metabolic disorders.
Bioorg Med Chem Lett
; 24(21): 5045-9, 2014 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25266782
2.
Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1).
Bioorg Med Chem Lett
; 24(2): 654-60, 2014 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24360604
3.
Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1).
Bioorg Med Chem Lett
; 21(22): 6699-704, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21983439
4.
Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1).
Bioorg Med Chem Lett
; 21(14): 4146-9, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21689935
5.
Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11ß-hydroxydehydrogenase 1 (11ß-HSD1).
Bioorg Med Chem Lett
; 21(22): 6693-8, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21983444
6.
Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase.
Bioorg Med Chem Lett
; 19(20): 5872-6, 2009 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19740659
7.
Cofactor-specific modulation of 11beta-hydroxysteroid dehydrogenase 1 inhibitor potency.
Biochim Biophys Acta
; 1774(9): 1184-91, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17707701
8.
A simple homogeneous scintillation proximity assay for acyl-coenzyme A:diacylglycerol acyltransferase.
Anal Biochem
; 383(2): 144-50, 2008 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18834848
9.
Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Bioorg Med Chem Lett
; 18(11): 3168-72, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18485702
10.
Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11ß-Hydroxysteroid Dehydrogenase Type 1 (11ß-HSD-1).
ACS Med Chem Lett
; 9(12): 1170-1174, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613321
11.
Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats.
Endocrinology
; 148(1): 4-12, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17008401
12.
Discovery of potent and muscle selective androgen receptor modulators through scaffold modifications.
J Med Chem
; 50(13): 3015-25, 2007 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17552509
13.
Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11ß-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.
J Med Chem
; 60(12): 4932-4948, 2017 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28537398
14.
Synthesis and characterization of 3-arylquinazolinone and 3-arylquinazolinethione derivatives as selective estrogen receptor beta modulators.
J Med Chem
; 49(8): 2440-55, 2006 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16610787
15.
Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold.
J Med Chem
; 49(26): 7596-9, 2006 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17181141
16.
Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.
J Med Chem
; 48(6): 2248-50, 2005 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15771468
17.
A homogeneous enzyme fragment complementation cyclic AMP screen for GPCR agonists.
J Biomol Screen
; 7(6): 515-25, 2002 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-14599349
18.
A sensitive, robust high-throughput electrochemiluminescence assay for rat insulin.
J Biomol Screen
; 9(1): 62-70, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15006150
19.
Characterization of a new class of selective nonsteroidal progesterone receptor agonists.
Steroids
; 69(3): 201-17, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15072922
20.
Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11ß-Hydroxysteroid Dehydrogenase Type 1 (11ß-HSD-1).
ACS Med Chem Lett
; 5(7): 803-8, 2014 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25050169