Detalhe da pesquisa
1.
Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents.
Arch Pharm (Weinheim)
; 357(4): e2300656, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38304944
2.
Clean Synthetic Strategies to Biologically Active Molecules from Lignin: A Green Path to Drug Discovery.
Angew Chem Int Ed Engl
; 63(4): e202308131, 2024 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37840425
3.
Facile Production of the Pseudomonas aeruginosa Virulence Factor LasB in Escherichia coli for Structure-Based Drug Design.
Chembiochem
; 24(17): e202300185, 2023 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37195753
4.
Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors.
Bioorg Chem
; 131: 106331, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36587505
5.
An Efficient Way to Screen Inhibitors of Energy-Coupling Factor (ECF) Transporters in a Bacterial Uptake Assay.
Int J Mol Sci
; 23(5)2022 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35269783
6.
Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors.
Angew Chem Int Ed Engl
; 61(5): e202112295, 2022 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34762767
7.
Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target-Guided Synthesis.
Angew Chem Int Ed Engl
; 61(39): e202203560, 2022 09 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35904863
8.
Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases.
J Am Chem Soc
; 139(36): 12696-12703, 2017 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28820255
9.
Synthesis and biological evaluation of 3-tetrazolo steroidal analogs: Novel class of 5α-reductase inhibitors.
Bioorg Med Chem
; 24(4): 779-88, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26780831
10.
Inhalable Clarithromycin Microparticles for Treatment of Respiratory Infections.
Pharm Res
; 32(12): 3850-61, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26113237
11.
New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent.
Antimicrob Agents Chemother
; 58(7): 4242-5, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24820077
12.
A detective story in drug discovery: elucidation of a screening artifact reveals polymeric carboxylic acids as potent inhibitors of RNA polymerase.
Chemistry
; 19(26): 8397-400, 2013 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23681768
13.
Exploring the Translational Gap of a Novel Class of Escherichia coli IspE Inhibitors.
ChemMedChem
; 18(19): e202300346, 2023 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37718320
14.
Not Every Hit-Identification Technique Works on 1-Deoxy-d-Xylulose 5-Phosphate Synthase (DXPS): Making the Most of a Virtual Screening Campaign.
ChemMedChem
; 18(11): e202200590, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36896721
15.
Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections.
ACS Cent Sci
; 9(12): 2205-2215, 2023 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38161367
16.
Contrast enhancement of the brain by folate-conjugated gadolinium-diethylenetriaminepentaacetic acid-human serum albumin nanoparticles by magnetic resonance imaging.
Mol Imaging
; 11(4): 272-9, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22954143
17.
The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB.
Antibiotics (Basel)
; 11(8)2022 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36009930
18.
Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters.
J Med Chem
; 65(13): 8869-8880, 2022 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35709475
19.
Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases.
J Med Chem
; 65(19): 12933-12955, 2022 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36154055
20.
Inhibition of Collagenase Q1 of Bacillus cereus as a Novel Antivirulence Strategy for the Treatment of Skin-Wound Infections.
Adv Ther (Weinh)
; 5(3): 2100222, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-35310821