Detalhe da pesquisa
1.
Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells.
Nature
; 620(7975): 881-889, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37558878
2.
An engineered bacterial therapeutic lowers urinary oxalate in preclinical models and in silico simulations of enteric hyperoxaluria.
Mol Syst Biol
; 18(3): e10539, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35253995
3.
Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b.
Immunity
; 35(2): 182-93, 2011 Aug 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21802320
4.
A phase 1/1b study of PUR1900, an inhaled formulation of itraconazole, in healthy volunteers and asthmatics to study safety, tolerability and pharmacokinetics.
Br J Clin Pharmacol
; 86(4): 723-733, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31696544
5.
Particle size and gastrointestinal absorption influence tiotropium pharmacokinetics: a pilot bioequivalence study of PUR0200 and Spiriva HandiHaler.
Br J Clin Pharmacol
; 85(3): 580-589, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30521129
6.
Pulmonary and Regional Deposition of Nebulized and Dry Powder Aerosols in Ferrets.
AAPS PharmSciTech
; 20(6): 242, 2019 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31264190
7.
Inhaled calcium salts inhibit tobacco smoke-induced inflammation by modulating expression of chemokines and cytokines.
Pulm Pharmacol Ther
; 53: 86-99, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30359782
8.
The pharmacokinetics, pharmacodynamics and tolerability of PUR0200, a novel tiotropium formulation, in chronic obstructive pulmonary disease.
Br J Clin Pharmacol
; 84(9): 2097-2105, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29790581
9.
Calcium restores the macrophage response to nontypeable haemophilus influenzae in chronic obstructive pulmonary disease.
Am J Respir Cell Mol Biol
; 52(6): 728-37, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25338285
10.
Rational Engineering of Escherichia coli Nissle 1917 as Live Biotherapeutic to Degrade Uremic Toxin Precursors.
ACS Synth Biol
; 13(4): 1077-1084, 2024 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38588591
11.
The live biotherapeutic SYNB1353 decreases plasma methionine via directed degradation in animal models and healthy volunteers.
Cell Host Microbe
; 32(3): 382-395.e10, 2024 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38309259
12.
Robust performance of a live bacterial therapeutic chassis lacking the colibactin gene cluster.
PLoS One
; 18(2): e0280499, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36730255
13.
Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies.
Clin Cancer Res
; 29(13): 2435-2444, 2023 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37227176
14.
Engineered bacteria producing aryl-hydrocarbon receptor agonists protect against ethanol-induced liver disease in mice.
Alcohol Clin Exp Res (Hoboken)
; 47(5): 856-867, 2023 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-36871955
15.
Engineered probiotics limit CNS autoimmunity by stabilizing HIF-1α in dendritic cells.
bioRxiv
; 2023 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36993446
16.
Evasion of peptide, but not lipid antigen presentation, through pathogen-induced dendritic cell maturation.
Proc Natl Acad Sci U S A
; 105(32): 11281-6, 2008 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18685099
17.
Allergic Diseases Caused by Aspergillus Species in Patients with Cystic Fibrosis.
Antibiotics (Basel)
; 10(4)2021 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33800658
18.
Synthetic biology: at the crossroads of genetic engineering and human therapeutics-a Keystone Symposia report.
Ann N Y Acad Sci
; 1506(1): 98-117, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34786712
19.
A New Natural Defense Against Airborne Pathogens.
QRB Discov
; 1: e5, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-34192261
20.
Serum lipids regulate dendritic cell CD1 expression and function.
Immunology
; 125(3): 289-301, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18445008