Detalhe da pesquisa
1.
Evaluation of RNAi therapeutics VIR-2218 and ALN-HBV for chronic hepatitis B: Results from randomized clinical trials.
J Hepatol
; 79(4): 924-932, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37290591
2.
Comprehensive evaluation of canonical versus Dicer-substrate siRNA in vitro and in vivo.
RNA
; 18(3): 557-68, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22294662
3.
Rare coding variants in DNA damage repair genes associated with timing of natural menopause.
HGG Adv
; 3(2): 100079, 2022 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35493704
4.
Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity.
Nat Commun
; 13(1): 4319, 2022 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35896531
5.
Gene-level analysis of rare variants in 379,066 whole exome sequences identifies an association of GIGYF1 loss of function with type 2 diabetes.
Sci Rep
; 11(1): 21565, 2021 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34732801
6.
GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms.
Nat Commun
; 12(1): 4571, 2021 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34315874
7.
Association of the transthyretin variant V122I with polyneuropathy among individuals of African ancestry.
Sci Rep
; 11(1): 11645, 2021 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34079032
8.
Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank.
Nat Genet
; 53(7): 942-948, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34183854
9.
Transthyretin-stabilising mutation T119M is not associated with protection against vascular disease or death in the UK Biobank.
Amyloid
; 27(3): 184-190, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-32425064
10.
First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement.
Cancer Discov
; 3(4): 406-17, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23358650
11.
Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models.
J Clin Invest
; 120(11): 3940-52, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20972333
12.
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.
Cell
; 124(6): 1283-98, 2006 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-16564017