Detalhe da pesquisa
1.
De Novo Sequencing of Synthetic Bis-cysteine Peptide Macrocycles Enabled by "Chemical Linearization" of Compound Mixtures.
Anal Chem
; 95(40): 14870-14878, 2023 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37724843
2.
bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA).
Proc Natl Acad Sci U S A
; 117(11): 5791-5800, 2020 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32123106
3.
Synthesis of Chiral Alkenyl Cyclopropane Amino Acids for Incorporation into Stapled Peptides.
J Org Chem
; 85(3): 1556-1566, 2020 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31825612
4.
An intramolecular tryptophan-condensation approach for peptide stapling.
Org Biomol Chem
; 16(3): 389-392, 2018 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29271460
5.
Palladium-meta-terarylphosphine catalyst for the Mizoroki-Heck reaction of (hetero)aryl bromides and functional olefins.
J Org Chem
; 80(8): 4054-63, 2015 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25768312
6.
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists.
Nat Commun
; 15(1): 489, 2024 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38216578
7.
Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein.
RSC Chem Biol
; 4(12): 1096-1110, 2023 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38033728
8.
A high-throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell-based assays.
Bioeng Transl Med
; 8(5): e10542, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37693049
9.
NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay.
ACS Chem Biol
; 16(2): 293-309, 2021 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33539064
10.
Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling.
Chem Sci
; 12(48): 15975-15987, 2021 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35024121
11.
De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits.
ACS Med Chem Lett
; 11(10): 1993-2001, 2020 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33062184
12.
Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability.
Chem Sci
; 11(21): 5577-5591, 2020 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32874502
13.
Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles.
Chem Sci
; 10(26): 6457-6466, 2019 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31316744
14.
Application of natural product-inspired diversity-oriented synthesis to drug discovery.
Prog Drug Res
; 66: 187, 189-216, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18416306
15.
In vitro and in vivo anticancer activities of synthetic (-)-laulimalide, a marine natural product microtubule stabilizing agent.
Anticancer Res
; 27(3B): 1509-18, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17595769
16.
Empirical and Computational Insights into N-Arylation Reactions Catalyzed by Palladium meta-Terarylphosphine Catalyst.
Chempluschem
; 82(5): 750-757, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-31961519
17.
A new route to bicyclo[1.1.1]pentan-1-amine from 1-azido-3-iodobicyclo[1.1.1]pentane.
Org Lett
; 16(7): 1884-7, 2014 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-24628135
18.
Stabilized Wittig olefination for bioconjugation.
Chem Commun (Camb)
; 49(95): 11188-90, 2013 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24150718
19.
Direct conversion of indoles to 3,3-difluoro-2-oxindoles via electrophilic fluorination.
Org Lett
; 14(22): 5676-9, 2012 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23101562
20.
Natural product-like synthetic libraries.
Curr Opin Chem Biol
; 15(4): 516-22, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21684804