Detalhe da pesquisa
1.
Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN).
Bioorg Med Chem Lett
; 29(8): 1001-1006, 2019 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30803804
2.
Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor.
J Med Chem
; 63(4): 1612-1623, 2020 02 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31971798
3.
Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors.
J Med Chem
; 62(14): 6575-6596, 2019 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31199148
4.
The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists.
Bioorg Med Chem Lett
; 18(3): 891-6, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18180159
5.
1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists.
Bioorg Med Chem Lett
; 18(18): 5027-31, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18752949
6.
Aminoquinazolines as TRPV1 antagonists: modulation of drug-like properties through the exploration of 2-position substitution.
Bioorg Med Chem Lett
; 18(16): 4573-7, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18662872
7.
Aminopyrazine CB1 receptor inverse agonists.
Bioorg Med Chem Lett
; 18(11): 3376-81, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18448340
8.
Synthesis of 2-aryl-oxazolo[4,5-c]quinoline-4(5H)-ones and 2-aryl-thiazolo[4,5-c]quinoline-4(5H)-ones.
Org Lett
; 5(16): 2911-4, 2003 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-12889906
9.
Regiocontrolled synthesis of substituted thiazoles.
Org Lett
; 4(8): 1363-5, 2002 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-11950363
10.
Ethyl 2-chlorooxazole-4-carboxylate: a versatile intermediate for the synthesis of substituted oxazoles.
Org Lett
; 4(17): 2905-7, 2002 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-12182585
11.
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
J Med Chem
; 53(8): 3330-48, 2010 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20307063