Detalhe da pesquisa
1.
Polypharmacological repurposing approach identifies approved drugs as potential inhibitors of Mycobacterium tuberculosis.
Biochem J
; 480(14): 1079-1096, 2023 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37306466
2.
Evolutionarily conserved heat shock protein, HtpX, as an adjunct target against antibiotic-resistant Neisseria gonorrhoeae.
J Cell Biochem
; 124(10): 1516-1529, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37566682
3.
Phosphorylation-mediated regulation of the Bacillus anthracis phosphoglycerate mutase by the Ser/Thr protein kinase PrkC.
Biochem Biophys Res Commun
; 665: 88-97, 2023 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37149987
4.
In-silico design of an immunoinformatics based multi-epitope vaccine against Leishmania donovani.
BMC Bioinformatics
; 23(1): 319, 2022 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35931960
5.
Energetics of Spike Protein Opening of SARS-CoV-1 and SARS-CoV-2 and Its Variants of Concern: Implications in Host Receptor Scanning and Transmission.
Biochemistry
; 61(20): 2188-2197, 2022 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36166360
6.
Antimicrobial-resistant Neisseria gonorrhoeae can be targeted using inhibitors against evolutionary conservedl-asparaginase.
J Cell Biochem
; 123(7): 1171-1182, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35527389
7.
Specific keratinase derived designer peptides potently inhibit Aß aggregation resulting in reduced neuronal toxicity and apoptosis.
Biochem J
; 476(12): 1817-1841, 2019 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31138770
8.
Identification and validation of l-asparaginase as a potential metabolic target against Mycobacterium tuberculosis.
J Cell Biochem
; 120(1): 143-154, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30230585
9.
The Gelsolin Pathogenic D187N Mutant Exhibits Altered Conformational Stability and Forms Amyloidogenic Oligomers.
Biochemistry
; 57(16): 2359-2372, 2018 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29637772
10.
Arjunolic acid, a peroxisome proliferator-activated receptor α agonist, regresses cardiac fibrosis by inhibiting non-canonical TGF-ß signaling.
J Biol Chem
; 292(40): 16440-16462, 2017 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28821620
11.
Biophysical insight into the heparin-peptide interaction and its modulation by a small molecule.
J Mol Recognit
; 31(1)2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28961341
12.
Modulation of prion polymerization and toxicity by rationally designed peptidomimetics.
Biochem J
; 474(1): 123-147, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27803245
13.
Clues for divergent, polymorphic amyloidogenesis through dissection of amyloid forming steps of bovine carbonic anhydrase and its critical amyloid forming stretch.
Biochim Biophys Acta
; 1864(7): 794-804, 2016 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-27045222
14.
Polyphenols in combination with ß-cyclodextrin can inhibit and disaggregate α-synuclein amyloids under cell mimicking conditions: A promising therapeutic alternative.
Biochim Biophys Acta Proteins Proteom
; 1865(5): 589-603, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-28238838
15.
Hyperthermophilic l-asparaginase bypasses monomeric intermediates during folding to retain cooperativity and avoid amyloid assembly.
Arch Biochem Biophys
; 622: 36-46, 2017 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28461187
16.
Curcumin binds to the pre-fibrillar aggregates of Cu/Zn superoxide dismutase (SOD1) and alters its amyloidogenic pathway resulting in reduced cytotoxicity.
Biochim Biophys Acta
; 1854(5): 426-36, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25666897
17.
Domains of Pyrococcus furiosus L-asparaginase fold sequentially and assemble through strong intersubunit associative forces.
Extremophiles
; 19(3): 681-91, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25862541
18.
Structural and functional insights into an archaeal L-asparaginase obtained through the linker-less assembly of constituent domains.
Acta Crystallogr D Biol Crystallogr
; 70(Pt 12): 3187-97, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25478837
19.
The Salmonella typhi Cell Division Activator Protein StCAP Impacts Pathogenesis by Influencing Critical Molecular Events.
ACS Infect Dis
; 10(6): 1990-2001, 2024 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38815059
20.
Hyperthermophilic asparaginase mutants with enhanced substrate affinity and antineoplastic activity: structural insights on their mechanism of action.
FASEB J
; 26(3): 1161-71, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22166247