Detalhe da pesquisa
1.
Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors.
Bioorg Med Chem Lett
; 88: 129304, 2023 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37119973
2.
Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain.
Med Chem Res
; : 1-7, 2023 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37362320
3.
Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors.
Bioorg Med Chem Lett
; 30(21): 127474, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32805407
4.
Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton's tyrosine kinase (BTK) and Janus kinase 2 (JAK2).
Bioorg Med Chem Lett
; 25(19): 4265-9, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26320619
5.
Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases.
Bioorg Med Chem Lett
; 24(9): 2206-11, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24685542
6.
Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors.
J Med Chem
; 65(5): 4121-4155, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35171586
7.
Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132).
J Med Chem
; 65(5): 4291-4317, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35179904
8.
Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of ß-secretase (BACE).
Bioorg Med Chem Lett
; 21(22): 6916-24, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21782431
9.
Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1.
Bioorg Med Chem Lett
; 21(1): 537-41, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21078556
10.
Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.
Bioorg Med Chem Lett
; 21(22): 6909-15, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21974952
11.
Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1).
Acta Crystallogr F Struct Biol Commun
; 77(Pt 1): 22-28, 2021 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33439152
12.
Discovery, Structure-Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain.
J Med Chem
; 64(15): 11090-11128, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34270254
13.
Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation.
Bioorg Med Chem Lett
; 20(9): 2933-7, 2010 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20356736
14.
Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).
J Med Chem
; 62(20): 8953-8972, 2019 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31314518
15.
Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.
J Med Chem
; 60(12): 5193-5208, 2017 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28541707
16.
Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers.
J Med Chem
; 59(19): 9173-9200, 2016 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27583770
17.
Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177).
J Med Chem
; 59(17): 7915-35, 2016 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27531604
18.
Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3(1,2).
J Med Chem
; 45(24): 5233-48, 2002 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12431051
19.
Acyl guanidine inhibitors of ß-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis.
J Med Chem
; 55(21): 9208-23, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23030502
20.
Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).
J Med Chem
; 53(7): 2854-64, 2010 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20218621