Detalhe da pesquisa
1.
Synthesis of a DNA-Encoded Macrocyclic Library Utilizing Intramolecular Benzimidazole Formation.
Bioconjug Chem
; 34(6): 988-993, 2023 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37216465
2.
Physiologic Targets and Modes of Action for CBL0137, a Lead for Human African Trypanosomiasis Drug Development.
Mol Pharmacol
; 102(1): 1-16, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35605992
3.
Application of l-Threonine Aldolase to on-DNA Reactions.
Bioconjug Chem
; 32(9): 1973-1978, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34424686
4.
The Aryl Hydrocarbon Receptor is a Critical Regulator of Tissue Factor Stability and an Antithrombotic Target in Uremia.
J Am Soc Nephrol
; 27(1): 189-201, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26019318
5.
Repurposing strategies for tropical disease drug discovery.
Bioorg Med Chem Lett
; 26(11): 2569-76, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27080183
6.
Evaluation of pyrrolidine and pyrazolone derivatives as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1).
Tetrahedron Lett
; 56(21): 2832-2835, 2015 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25977593
7.
In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo.
Mol Pharmacol
; 86(5): 593-608, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25159092
8.
A chemical screen identifies small molecules that regulate hepcidin expression.
Blood Cells Mol Dis
; 53(4): 231-40, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24998898
9.
Repurposing human PDE4 inhibitors for neglected tropical diseases: design, synthesis and evaluation of cilomilast analogues as Trypanosoma brucei PDEB1 inhibitors.
Bioorg Med Chem Lett
; 24(17): 4084-9, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25127163
10.
Synthesis and assessment of catechol diether compounds as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1).
Bioorg Med Chem Lett
; 23(21): 5971-4, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24042005
11.
Chemical Optimization of CBL0137 for Human African Trypanosomiasis Lead Drug Discovery.
J Med Chem
; 66(3): 1972-1989, 2023 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36695630
12.
Structure-Property Optimization of a Series of Imidazopyridines for Visceral Leishmaniasis.
ACS Infect Dis
; 9(8): 1470-1487, 2023 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37417544
13.
Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes.
Front Microbiol
; 14: 1149145, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37234530
14.
Corrigendum: Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes.
Front Microbiol
; 14: 1304196, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37954236
15.
Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 2. Tadalafil analogs.
Bioorg Med Chem Lett
; 22(7): 2582-4, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22377518
16.
Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 1. Sildenafil analogs.
Bioorg Med Chem Lett
; 22(7): 2579-81, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22370268
17.
Kinases as druggable targets in trypanosomatid protozoan parasites.
Chem Rev
; 114(22): 11280-304, 2014 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-26443079
18.
Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis.
J Med Chem
; 64(13): 9404-9430, 2021 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34156862
19.
Neutralizing positive charges at the surface of a protein lowers its rate of amide hydrogen exchange without altering its structure or increasing its thermostability.
J Am Chem Soc
; 132(49): 17411-25, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21090618
20.
Medicinal Chemistry Optimization of a Diaminopurine Chemotype: Toward a Lead for Trypanosoma brucei Inhibitors.
J Med Chem
; 63(17): 9912-9927, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32786222