Detalhe da pesquisa
1.
Significance of Organic Anion Transporter 2 and Organic Cation Transporter 2 in Creatinine Clearance: Mechanistic Evaluation Using Freshly Prepared Human Primary Renal Proximal Tubule Cells.
J Pharmacol Exp Ther
; 388(1): 201-208, 2024 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37977812
2.
Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles.
Proteomics
; : e2300025, 2023 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38037300
3.
Characterization of Bile Acid Sulfate Conjugates as Substrates of Human Organic Anion Transporting Polypeptides.
Mol Pharm
; 20(6): 3020-3032, 2023 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37134201
4.
Utilization of Rosuvastatin and Endogenous Biomarkers in Evaluating the Impact of Ritlecitinib on BCRP, OATP1B1, and OAT3 Transporter Activity.
Pharm Res
; 40(11): 2639-2651, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37561322
5.
Cynomolgus Monkey as an Emerging Animal Model to Study Drug Transporters: In Vitro, In Vivo, In Vitro-to-In Vivo Translation.
Drug Metab Dispos
; 50(3): 299-319, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34893475
6.
Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, A First-in-class Ketohexokinase Inhibitor for Metabolic Disorders and Non-alcoholic Fatty Liver Disease.
Drug Metab Dispos
; 2022 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35779864
7.
Effect of Human Plasma on Hepatic Uptake of Organic Anion-Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes.
Drug Metab Dispos
; 49(1): 72-83, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33139461
8.
Role of Extracellular Vesicle-Derived Biomarkers in Drug Metabolism and Disposition.
Drug Metab Dispos
; 49(11): 961-971, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34353847
9.
A Multiplexed HILIC-MS/HRMS Assay for the Assessment of Transporter Inhibition Biomarkers in Phase I Clinical Trials: Isobutyryl-Carnitine as an Organic Cation Transporter (OCT1) Biomarker.
Anal Chem
; 92(14): 9745-9754, 2020 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551505
10.
Profiling of Drug-Metabolizing Enzymes and Transporters in Human Tissue Biopsy Samples: A Review of the Literature.
J Pharmacol Exp Ther
; 372(3): 308-319, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31879375
11.
Induction of Human Intestinal and Hepatic Organic Anion Transporting Polypeptides: Where Is the Evidence for Its Relevance in Drug-Drug Interactions?
Drug Metab Dispos
; 48(3): 205-216, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31879282
12.
Moving beyond Binary Predictions of Human Drug-Induced Liver Injury (DILI) toward Contrasting Relative Risk Potential.
Chem Res Toxicol
; 33(1): 223-238, 2020 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31532188
13.
Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes.
J Pharmacol Exp Ther
; 370(1): 72-83, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30975793
14.
Mechanistic Evaluation of the Complex Drug-Drug Interactions of Maraviroc: Contribution of Cytochrome P450 3A, P-Glycoprotein and Organic Anion Transporting Polypeptide 1B1.
Drug Metab Dispos
; 47(5): 493-503, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30862625
15.
Renal Excretion of Dabigatran: The Potential Role of Multidrug and Toxin Extrusion (MATE) Proteins.
Mol Pharm
; 16(9): 4065-4076, 2019 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31335150
16.
Plasma extracellular nanovesicle (exosome)-derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure.
Br J Clin Pharmacol
; 85(1): 216-226, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30340248
17.
In Vitro-In Vivo Extrapolation of OATP1B-Mediated Drug-Drug Interactions in Cynomolgus Monkey.
J Pharmacol Exp Ther
; 365(3): 688-699, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29643253
18.
Organic Anion Transporter 2 Mediates Hepatic Uptake of Tolbutamide, a CYP2C9 Probe Drug.
J Pharmacol Exp Ther
; 364(3): 390-398, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29326367
19.
Human Pluripotent Stem Cell-Derived Kidney Model for Nephrotoxicity Studies.
Drug Metab Dispos
; 46(11): 1703-1711, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30171163
20.
Physiologically Relevant, Humanized Intestinal Systems to Study Metabolism and Transport of Small Molecule Therapeutics.
Drug Metab Dispos
; 46(11): 1581-1587, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30126862