Detalhe da pesquisa
1.
NF-κB activation in astrocytes drives a stage-specific beneficial neuroimmunological response in ALS.
EMBO J
; 37(16)2018 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29875132
2.
Selective Cannabinoid 2 Receptor Agonists as Potential Therapeutic Drugs for the Treatment of Endotoxin-Induced Uveitis.
Molecules
; 24(18)2019 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31540271
3.
Adventures in drug-like chemistry space: from oxetanes to spiroazetidines and beyond!
Chimia (Aarau)
; 68(7-8): 492-9, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25437389
4.
Highly potent and selective cannabinoid receptor 2 agonists: initial hit optimization of an adamantyl hit series identified from high-through-put screening.
Bioorg Med Chem Lett
; 23(5): 1177-81, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23380378
5.
BACE1 inhibitors: a head group scan on a series of amides.
Bioorg Med Chem Lett
; 23(14): 4239-43, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23735744
6.
Behavioral analysis through the lifespan of disc1 mutant zebrafish identifies defects in sensorimotor transformation.
iScience
; 26(7): 107099, 2023 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37416451
7.
Oxetanes as versatile elements in drug discovery and synthesis.
Angew Chem Int Ed Engl
; 49(48): 9052-67, 2010 Nov 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-21031377
8.
Discovery of Balovaptan, a Vasopressin 1a Receptor Antagonist for the Treatment of Autism Spectrum Disorder.
J Med Chem
; 63(4): 1511-1525, 2020 02 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31951127
9.
Benzodioxoles: novel cannabinoid-1 receptor inverse agonists for the treatment of obesity.
J Med Chem
; 51(7): 2115-27, 2008 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18335976
10.
Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases.
ChemMedChem
; 11(2): 179-89, 2016 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26228928
11.
Ligand identification for G-protein-coupled receptors: a lead generation perspective.
Curr Opin Chem Biol
; 8(3): 287-96, 2004 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15183327
12.
Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach.
J Med Chem
; 58(5): 2275-89, 2015 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25654260
13.
Development of a virtual screening method for identification of "frequent hitters" in compound libraries.
J Med Chem
; 45(1): 137-42, 2002 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-11754585
14.
A concise asymmetric route to the bridged bicyclic tropane alkaloid ferruginine using enyne ring-closing metathesis.
Org Lett
; 6(9): 1469-71, 2004 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-15101769
15.
Spirocyclic oxetanes: synthesis and properties.
Angew Chem Int Ed Engl
; 47(24): 4512-5, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18465828
16.
Construction of multifunctional modules for drug discovery: synthesis of novel thia/oxa-azaspiro[3.4]octanes.
Org Lett
; 15(18): 4766-9, 2013 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23991674
17.
Synthesis and stability of oxetane analogs of thalidomide and lenalidomide.
Org Lett
; 15(17): 4312-5, 2013 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23937240
18.
ß-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease.
J Med Chem
; 56(10): 3980-95, 2013 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-23590342
19.
Oxetanes as promising modules in drug discovery.
Angew Chem Int Ed Engl
; 45(46): 7736-9, 2006 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-17013952
20.
Synthesis of novel azaspiro[3.4]octanes as multifunctional modules in drug discovery.
Org Lett
; 13(22): 6134-6, 2011 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22007769