Detalhe da pesquisa
1.
An optimized agonist peptide of protease-activated receptor 4 and its use in a validated platelet-aggregation assay.
Platelets
; 33(7): 979-986, 2022 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35343875
2.
Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure.
Circulation
; 141(18): 1463-1476, 2020 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32237898
3.
Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa.
Bioorg Med Chem Lett
; 30(4): 126949, 2020 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31932224
4.
Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability.
Bioorg Med Chem Lett
; 29(19): 126604, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31445854
5.
Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors.
Bioorg Med Chem Lett
; 28(6): 987-992, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29501396
6.
Factor XIIa as a Novel Target for Thrombosis: Target Engagement Requirement and Efficacy in a Rabbit Model of Microembolic Signals.
J Pharmacol Exp Ther
; 360(3): 466-475, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28035006
7.
Macrocyclic factor XIa inhibitors.
Bioorg Med Chem Lett
; 27(17): 4056-4060, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28780160
8.
Neutral macrocyclic factor VIIa inhibitors.
Bioorg Med Chem Lett
; 27(12): 2650-2654, 2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28460818
9.
Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency.
Bioorg Med Chem Lett
; 27(16): 3833-3839, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28687203
10.
Novel phenylalanine derived diamides as Factor XIa inhibitors.
Bioorg Med Chem Lett
; 26(2): 472-478, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26704266
11.
Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group.
Bioorg Med Chem
; 24(10): 2257-72, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27073051
12.
Pyridine and pyridinone-based factor XIa inhibitors.
Bioorg Med Chem Lett
; 25(4): 925-30, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25592713
13.
Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties.
Bioorg Med Chem Lett
; 25(7): 1635-42, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25728130
14.
In vitro, antithrombotic and bleeding time studies of BMS-654457, a small-molecule, reversible and direct inhibitor of factor XIa.
J Thromb Thrombolysis
; 40(4): 416-23, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26249722
15.
Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent.
Bioorg Med Chem Lett
; 24(5): 1294-8, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24513044
16.
Proteomic Associations of NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) in Heart Failure With Preserved Ejection Fraction.
Circ Heart Fail
; 17(2): e011146, 2024 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38299345
17.
Proteomic Associations of Adverse Outcomes in Human Heart Failure.
J Am Heart Assoc
; 13(5): e031154, 2024 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38420755
18.
Discovery of diarylurea P2Y(1) antagonists with improved aqueous solubility.
Bioorg Med Chem Lett
; 23(11): 3239-43, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23602442
19.
Proteomic Correlates of the Urinary Protein/Creatinine Ratio in Heart Failure With Preserved Ejection Fraction.
Am J Cardiol
; 206: 312-319, 2023 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37734292
20.
Proteomic Analysis of Effects of Spironolactone in Heart Failure With Preserved Ejection Fraction.
Circ Heart Fail
; 15(9): e009693, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36126144