Detalhe da pesquisa
1.
Evaluation of the effect of rifampin on the pharmacokinetics of the Smoothened inhibitor glasdegib in healthy volunteers.
Br J Clin Pharmacol
; 84(6): 1346-1353, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29488303
2.
Metabolism, excretion and pharmacokinetics of [14C]glasdegib (PF-04449913) in healthy volunteers following oral administration.
Xenobiotica
; 47(12): 1064-1076, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27866461
3.
Randomized comparison of low dose cytarabine with or without glasdegib in patients with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome.
Leukemia
; 33(2): 379-389, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30555165
4.
Phase Ib Study of Glasdegib, a Hedgehog Pathway Inhibitor, in Combination with Standard Chemotherapy in Patients with AML or High-Risk MDS.
Clin Cancer Res
; 24(10): 2294-2303, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29463550
5.
Evaluation of the effect of new formulation, food, or a proton pump inhibitor on the relative bioavailability of the smoothened inhibitor glasdegib (PF-04449913) in healthy volunteers.
Cancer Chemother Pharmacol
; 80(6): 1249-1260, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29086063
6.
Phase I study of the gamma secretase inhibitor PF-03084014 in combination with docetaxel in patients with advanced triple-negative breast cancer.
Oncotarget
; 8(2): 2320-2328, 2017 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27906684
7.
A phase I study of PF-04449913, an oral hedgehog inhibitor, in patients with advanced solid tumors.
Clin Cancer Res
; 21(5): 1044-51, 2015 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25388167
8.
Treatment with PF-04449913, an oral smoothened antagonist, in patients with myeloid malignancies: a phase 1 safety and pharmacokinetics study.
Lancet Haematol
; 2(8): e339-46, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26688487
9.
A Phase I, dose-finding study in patients with advanced solid malignancies of the oral γ-secretase inhibitor PF-03084014.
Clin Cancer Res
; 21(1): 60-7, 2015 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25231399
10.
Evaluation of the effect of food and ketoconazole on the pharmacokinetics of the smoothened inhibitor PF-04449913 in healthy volunteers.
Cancer Chemother Pharmacol
; 74(2): 411-8, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24944041
11.
Phase I study of the CD40 agonist antibody CP-870,893 combined with carboplatin and paclitaxel in patients with advanced solid tumors.
Oncoimmunology
; 2(1): e23033, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23483678
12.
Phase I, dose-escalation trial of the oral cyclin-dependent kinase 4/6 inhibitor PD 0332991, administered using a 21-day schedule in patients with advanced cancer.
Clin Cancer Res
; 18(2): 568-76, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22090362