Detalhe da pesquisa
1.
The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems.
J Org Chem
; 81(9): 3509-19, 2016 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27056793
2.
Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Bioorg Med Chem Lett
; 25(22): 5352-6, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26411795
3.
Synthesis of 7-oxo-dihydrospiro[indazole-5,4'-piperidine] acetyl-CoA carboxylase inhibitors.
J Org Chem
; 77(3): 1497-506, 2012 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22239115
4.
Synthesis of spiropiperidine lactam acetyl-CoA carboxylase inhibitors.
J Org Chem
; 77(22): 10050-7, 2012 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23127254
5.
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.
Bioorg Med Chem Lett
; 22(24): 7523-9, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23153798
6.
Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists.
Bioorg Med Chem Lett
; 19(9): 2400-3, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19346127
7.
Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes.
J Med Chem
; 57(24): 10512-26, 2014 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25423286
8.
Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure.
J Med Chem
; 56(17): 7110-9, 2013 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23981033
9.
Metabolism-guided design of short-acting calcium-sensing receptor antagonists.
ACS Med Chem Lett
; 1(5): 219-23, 2010 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900198