Detalhe da pesquisa
1.
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.
Proc Natl Acad Sci U S A
; 108(17): 6811-6, 2011 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21398589
2.
Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry--activity-based protein profiling.
Biochemistry
; 52(51): 9187-201, 2013 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-24320749
3.
Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2).
Bioorg Med Chem Lett
; 23(3): 839-43, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23260346
4.
Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes.
J Am Chem Soc
; 134(25): 10345-8, 2012 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22690931
5.
Rapid development of a potent photo-triggered inhibitor of the serine hydrolase RBBP9.
Chembiochem
; 13(14): 2082-93, 2012 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22907802
6.
Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners.
Biochemistry
; 50(51): 11143-61, 2011 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22074223
7.
Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance.
J Am Chem Soc
; 133(41): 16605-16, 2011 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21899313
8.
A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors.
J Am Chem Soc
; 133(30): 11665-74, 2011 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-21692504
9.
Ligands in crystal structures that aid in functional characterization.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 66(Pt 10): 1306-8, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20944226
10.
Chromatographic benefits of elevated temperature for the proteomic analysis of membrane proteins.
Proteomics
; 8(19): 3956-64, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18780350
11.
Profiling enzyme activities in vivo using click chemistry methods.
Chem Biol
; 11(4): 535-46, 2004 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15123248
12.
Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival.
ACS Chem Biol
; 10(4): 925-32, 2015 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25602368
13.
Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis.
ACS Chem Biol
; 10(2): 364-71, 2015 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25457457
14.
Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis.
J Med Chem
; 56(21): 8257-69, 2013 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24152245
15.
Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/ß-hydrolase domain containing 6 (ABHD6).
J Med Chem
; 56(21): 8270-9, 2013 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24152295
16.
Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase().
Chem Sci
; 3(1): 77-83, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22737400
17.
Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1.
J Med Chem
; 54(14): 5229-36, 2011 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21639134
18.
Activity-Based Protein Profiling (ABPP) and Click Chemistry (CC)-ABPP by MudPIT Mass Spectrometry.
Curr Protoc Chem Biol
; 1: 29-41, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-21701697
19.
A shotgun proteomic method for the identification of membrane-embedded proteins and peptides.
J Proteome Res
; 7(7): 3028-34, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18537282
20.
Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP)--a general method for mapping sites of probe modification in proteomes.
Nat Protoc
; 2(6): 1414-25, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17545978