Detalhe da pesquisa
1.
Type I interferon blockade with anifrolumab in patients with systemic lupus erythematosus modulates key immunopathological pathways in a gene expression and proteomic analysis of two phase 3 trials.
Ann Rheum Dis
; 2024 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38569851
2.
Benralizumab in children with severe eosinophilic asthma: Pharmacokinetics and long-term safety (TATE study).
Pediatr Allergy Immunol
; 35(3): e14092, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38491795
3.
The VICM biomarker is released from activated macrophages and inhibited by anti-GM-CSFRα-mAb treatment in rheumatoid arthritis patients.
Clin Exp Rheumatol
; 37(1): 73-80, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30418117
4.
Blockade of GM-CSF pathway induced sustained suppression of myeloid and T cell activities in rheumatoid arthritis.
Rheumatology (Oxford)
; 57(1): 175-184, 2018 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29069507
5.
Cytokine-Induced Glucocorticoid Resistance from Eosinophil Activation: Protein Phosphatase 5 Modulation of Glucocorticoid Receptor Phosphorylation and Signaling.
J Immunol
; 197(10): 3782-3791, 2016 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27742828
6.
Autoreactive CD19+CD20- Plasma Cells Contribute to Disease Severity of Experimental Autoimmune Encephalomyelitis.
J Immunol
; 196(4): 1541-9, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26764035
7.
Activation of Human Peripheral Blood Eosinophils by Cytokines in a Comparative Time-Course Proteomic/Phosphoproteomic Study.
J Proteome Res
; 16(8): 2663-2679, 2017 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28679203
8.
Statistical Models for the Analysis of Isobaric Tags Multiplexed Quantitative Proteomics.
J Proteome Res
; 16(9): 3124-3136, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28745510
9.
A randomised phase IIb study of mavrilimumab, a novel GM-CSF receptor alpha monoclonal antibody, in the treatment of rheumatoid arthritis.
Ann Rheum Dis
; 76(6): 1020-1030, 2017 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28213566
10.
A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients.
Ann Rheum Dis
; 73(1): 256-62, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23434567
11.
Suppression of soluble T cell-associated proteins by an anti-interferon-α monoclonal antibody in adult patients with dermatomyositis or polymyositis.
Rheumatology (Oxford)
; 53(4): 686-95, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24357810
12.
Sifalimumab, a human anti-interferon-α monoclonal antibody, in systemic lupus erythematosus: a phase I randomized, controlled, dose-escalation study.
Arthritis Rheum
; 65(4): 1011-21, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23400715
13.
Clinical Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Anifrolumab.
Clin Pharmacokinet
; 62(5): 655-671, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37148484
14.
Urinary markers differentially associate with kidney inflammatory activity and chronicity measures in patients with lupus nephritis.
Lupus Sci Med
; 10(1)2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36717181
15.
Relationship Between Anifrolumab Pharmacokinetics, Pharmacodynamics, and Efficacy in Patients With Moderate to Severe Systemic Lupus Erythematosus.
J Clin Pharmacol
; 62(9): 1094-1105, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35352835
16.
Nonlinear Population Pharmacokinetics of Anifrolumab in Healthy Volunteers and Patients With Systemic Lupus Erythematosus.
J Clin Pharmacol
; 62(9): 1106-1120, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35383948
17.
Safety profile and clinical activity of sifalimumab, a fully human anti-interferon α monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study.
Ann Rheum Dis
; 70(11): 1905-13, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21798883
18.
Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway.
Ann Rheum Dis
; 70(11): 2029-36, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21803750
19.
Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma.
BMC Pulm Med
; 11: 14, 2011 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21356110
20.
Collagen Type III and VI Remodeling Biomarkers Are Associated with Kidney Fibrosis in Lupus Nephritis.
Kidney360
; 2(9): 1473-1481, 2021 09 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-35373114