Detalhe da pesquisa
1.
Discovery of pyridyl sulfonamide 11-beta-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors for the treatment of metabolic disorders.
Bioorg Med Chem Lett
; 24(21): 5045-9, 2014 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25266782
2.
Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold.
Bioorg Med Chem Lett
; 23(18): 5239-43, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23927973
3.
Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11ß-hydroxydehydrogenase 1 (11ß-HSD1).
Bioorg Med Chem Lett
; 21(22): 6693-8, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21983444
4.
Cofactor-specific modulation of 11beta-hydroxysteroid dehydrogenase 1 inhibitor potency.
Biochim Biophys Acta
; 1774(9): 1184-91, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17707701
5.
Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Bioorg Med Chem Lett
; 18(11): 3168-72, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18485702
6.
Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors.
J Med Chem
; 50(13): 2967-80, 2007 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17536795
7.
Aminoimidazoles as bioisosteres of acylguanidines: novel, potent, selective and orally bioavailable inhibitors of the sodium hydrogen exchanger isoform-1.
Bioorg Med Chem Lett
; 14(1): 177-80, 2004 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-14684323
8.
Design, synthesis, and biological activity of novel factor Xa inhibitors: 4-aryloxy substituents of 2,6-diphenoxypyridines.
Bioorg Med Chem
; 10(3): 657-66, 2002 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-11814853
9.
Structure-activity relationships of substituted benzothiophene-anthranilamide factor Xa inhibitors.
Bioorg Med Chem Lett
; 13(3): 507-11, 2003 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-12565961