Detalhe da pesquisa
1.
HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms.
Blood
; 135(3): 191-207, 2020 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31750881
2.
Discovery of novel biaryl sulfonamide based Mcl-1 inhibitors.
Bioorg Med Chem Lett
; 29(16): 2375-2382, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31235261
3.
Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11.
Bioorg Med Chem Lett
; 28(12): 2143-2147, 2018 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29776742
4.
Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.
Bioorg Med Chem Lett
; 25(3): 529-41, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25556090
5.
Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase.
Chembiochem
; 15(8): 1121-30, 2014 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24797455
6.
Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
Bioorg Med Chem Lett
; 24(1): 337-43, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24279990
7.
Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett
; 24(3): 954-62, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24433859
8.
Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett
; 23(17): 4875-85, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23899614
9.
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett
; 23(20): 5488-97, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24021463
10.
Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.
Bioorg Med Chem Lett
; 23(12): 3531-8, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23668988
11.
IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial.
Nat Med
; 29(12): 3127-3136, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37957373
12.
Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.
Bioorg Med Chem Lett
; 20(15): 4359-63, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20615696
13.
Novel HDAC11 inhibitors suppress lung adenocarcinoma stem cell self-renewal and overcome drug resistance by suppressing Sox2.
Sci Rep
; 10(1): 4722, 2020 03 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32170113
14.
Biaryl purine derivatives as potent antiproliferative agents: inhibitors of cyclin dependent kinases. Part I.
Bioorg Med Chem Lett
; 19(23): 6608-12, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19846305
15.
Heterobiaryl purine derivatives as potent antiproliferative agents: inhibitors of cyclin dependent kinases. Part II.
Bioorg Med Chem Lett
; 19(23): 6613-7, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19854650
16.
Aminoquinazolines as TRPV1 antagonists: modulation of drug-like properties through the exploration of 2-position substitution.
Bioorg Med Chem Lett
; 18(16): 4573-7, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18662872
17.
Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6.
Cell Rep
; 20(12): 2860-2875, 2017 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28930682
18.
Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors.
J Med Chem
; 59(18): 8345-68, 2016 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27541271
19.
Design, synthesis, and biological evaluation of substituted 2-cyclohexyl-4-phenyl-1H-imidazoles: potent and selective neuropeptide Y Y5-receptor antagonists.
J Med Chem
; 47(9): 2318-25, 2004 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-15084130
20.
Design, synthesis, molecular modeling studies, and calpain inhibitory activity of novel alpha-ketoamides incorporating polar residues at the P1'-position.
J Med Chem
; 47(1): 72-9, 2004 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14695821