Pesquisa | Portal de Pesquisa da BVS

1.

Leveraging Human Genetics to Estimate Clinical Risk Reductions Achievable by Inhibiting Factor XI.

Georgi, Benjamin; Mielke, Johanna; Chaffin, Mark; Khera, Amit V; Gelis, Lian; Mundl, Hardi; van Giezen, J J J; Ellinor, Patrick; Kathiresan, Sekar; Ziegelbauer, Karl; Freitag, Daniel F.

Stroke ; 50(11): 3004-3012, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-31558144

2.

Gradual increase in thrombogenicity of juvenile platelets formed upon offset of prasugrel medication.

Baaten, Constance C F M J; Veenstra, Leo F; Wetzels, Rick; van Geffen, Johanna P; Swieringa, Frauke; de Witt, Susanne M; Henskens, Yvonne M C; Crijns, Harry; Nylander, Sven; van Giezen, J J J; Heemskerk, Johan W M; van der Meijden, Paola E J.

Haematologica ; 100(9): 1131-8, 2015 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-26113418

3.

Optimization of ketone-based P2Y(12) receptor antagonists as antithrombotic agents: pharmacodynamics and receptor kinetics considerations.

Giordanetto, Fabrizio; Bach, Peter; Zetterberg, Fredrik; Antonsson, Thomas; Bylund, Ruth; Johansson, Johan; Sellén, Mikael; Brown, David; Hideståhl, Lotta; Berntsson, Pia; Hovdal, Daniel; Zachrisson, Helen; Björkman, Jan-Arne; van Giezen, J J J.

Bioorg Med Chem Lett ; 24(13): 2963-8, 2014 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-24835983

4.

A novel series of piperazinyl-pyridine ureas as antagonists of the purinergic P2Y12 receptor.

Bach, Peter; Boström, Jonas; Brickmann, Kay; van Giezen, J J J; Hovland, Ragnar; Petersson, Annika U; Ray, Asim; Zetterberg, Fredrik.

Bioorg Med Chem Lett ; 21(10): 2877-81, 2011 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-21507636

5.

Characterization of the adenosine pharmacology of ticagrelor reveals therapeutically relevant inhibition of equilibrative nucleoside transporter 1.

Armstrong, Duncan; Summers, Claire; Ewart, Lorna; Nylander, Sven; Sidaway, James E; van Giezen, J J J.

J Cardiovasc Pharmacol Ther ; 19(2): 209-19, 2014 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-24414167

6.

Synthesis, structure-property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y12 receptor.

Bach, Peter; Boström, Jonas; Brickmann, Kay; van Giezen, J J J; Groneberg, Robert D; Harvey, Darren M; O'Sullivan, Michael; Zetterberg, Fredrik.

Eur J Med Chem ; 65: 360-75, 2013 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-23747805

7.

Ticagrelor enhances adenosine-induced coronary vasodilatory responses in humans.

Wittfeldt, Ann; Emanuelsson, Håkan; Brandrup-Wognsen, Gunnar; van Giezen, J J J; Jonasson, Jenny; Nylander, Sven; Gan, Li-Ming.

J Am Coll Cardiol ; 61(7): 723-7, 2013 Feb 19.

Artigo em Inglês | MEDLINE | ID: mdl-23312702

8.

Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283.

Bach, Peter; Antonsson, Thomas; Bylund, Ruth; Björkman, Jan-Arne; Österlund, Krister; Giordanetto, Fabrizio; van Giezen, J J J; Andersen, Søren M; Zachrisson, Helen; Zetterberg, Fredrik.

J Med Chem ; 56(17): 7015-24, 2013 Sep 12.

Artigo em Inglês | MEDLINE | ID: mdl-23899349

9.

Ticagrelor inhibits adenosine uptake in vitro and enhances adenosine-mediated hyperemia responses in a canine model.

van Giezen, J J J; Sidaway, James; Glaves, Philip; Kirk, Ian; Björkman, Jan-Arne.

J Cardiovasc Pharmacol Ther ; 17(2): 164-72, 2012 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-21697355

10.

Evaluation of ticagrelor pharmacodynamic interactions with reversibly binding or non-reversibly binding P2Y(12) antagonists in an ex-vivo canine model.

Ravnefjord, Anna; Weilitz, Jessika; Emanuelsson, Britt-Marie; van Giezen, J J J.

Thromb Res ; 130(4): 622-8, 2012 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-22909827

11.

Role of newly formed platelets in thrombus formation in rat after clopidogrel treatment: comparison to the reversible binding P2Y12 antagonist ticagrelor.

Kuijpers, Marijke J E; Megens, Remco T A; Nikookhesal, Elham; Feijge, Marion A H; De Mey, J G R; oude Egbrink, Mirjam G A; van Giezen, J J J; Heemskerk, Johan W M.

Thromb Haemost ; 106(6): 1179-88, 2011 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-22071958

12.

Adjunctive treatment with ticagrelor, but not clopidogrel, added to tPA enables sustained coronary artery recanalisation with recovery of myocardium perfusion in a canine coronary thrombosis model.

Wang, Kai; Zhou, Xiaorong; Huang, Yanming; Khalil, Mazen; Wiktor, Dominik; van Giezen, J J J; Penn, Marc S.

Thromb Haemost ; 104(3): 609-17, 2010 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-20694285

13.

Stabilizing role of platelet P2Y(12) receptors in shear-dependent thrombus formation on ruptured plaques.

Nergiz-Unal, Reyhan; Cosemans, Judith M E M; Feijge, Marion A H; van der Meijden, Paola E J; Storey, Robert F; van Giezen, J J J; oude Egbrink, Mirjam G A; Heemskerk, Johan W M; Kuijpers, Marijke J E.

PLoS One ; 5(4): e10130, 2010 Apr 12.

Artigo em Inglês | MEDLINE | ID: mdl-20405028

14.

Ticagrelor: the first reversibly binding oral P2Y12 receptor antagonist.

Husted, Steen; van Giezen, J J J.

Cardiovasc Ther ; 27(4): 259-74, 2009.

Artigo em Inglês | MEDLINE | ID: mdl-19604248

15.

Comparison of ticagrelor and thienopyridine P2Y(12) binding characteristics and antithrombotic and bleeding effects in rat and dog models of thrombosis/hemostasis.

van Giezen, J J J; Berntsson, Pia; Zachrisson, Helen; Björkman, Jan-Arne.

Thromb Res ; 124(5): 565-71, 2009 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-19692114

16.

Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation.

VAN Giezen, J J J; Nilsson, L; Berntsson, P; Wissing, B-M; Giordanetto, F; Tomlinson, W; Greasley, P J.

J Thromb Haemost ; 7(9): 1556-65, 2009 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-19552634

17.

Reply: To PMID 23312702.

Gan, Li-Ming; Wittfeldt, Ann; Brandrup-Wognsen, Gunnar; van Giezen, J J J; Jonasson, Jenny; Nylander, Sven; Emanuelsson, Håkan.

J Am Coll Cardiol ; 62(7): 647, 2013 Aug 13.

Artigo em Inglês | MEDLINE | ID: mdl-23747784

18.

Evaluation of platelet function, a method comparison.

Nylander, S; Johansson, K; Van Giezen, J J J; Lindahl, T L.

Platelets ; 17(1): 49-55, 2006 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-16308187

19.

Preclinical and clinical studies with selective reversible direct P2Y12 antagonists.

van Giezen, J J J; Humphries, Robert G.

Semin Thromb Hemost ; 31(2): 195-204, 2005 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-15852223

20.

Dyspnoea and antiplatelet agents: revisited.

Husted, S; van Giezen, J J J.

Int J Clin Pract ; 61(9): 1590; author reply 1591, 2007 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-17686098

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