Suckling by Schistosoma mansoni-infected mothers restored IgG2a and TGF-β production, but not IL-6 and delayed-type hypersensitivity in IL-12/IL-23-deficient mice
Rev. Soc. Bras. Med. Trop
; Rev. Soc. Bras. Med. Trop;54: e0744-2020, 2021. tab, graf
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| ID: biblio-1155546
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ABSTRACT
Abstract INTRODUCTION Suckling by schistosomotic mice improves anti-ovalbumin (OA) antibody production, while delayed-type hypersensitivity (DTH) remains unaffected. This property of milk from schistosomotic mice was investigated in IL-12/IL-23-deficient mice (IL-12p40KO). METHODS We compared anti-OA DTH, IgG2a and cytokines in wild-type and IL-12p40KO mice suckled by infected (SIM) or non-infected (CONTROL) mothers. RESULTS SIM mice showed similar intensity and eosinophils in the DTH, which was abolished in IL-12p40KO and IL-12p40KO-SIM mice. In IL-12p40KO-SIM, IgG2a and TGF-β levels were higher, but IL-6 levels were lower. CONCLUSIONS Milk from schistosomotic mothers may evoke IgG2a without eliciting DTH in IL-12/IL-23 deficiencies, by changing TGF-β/IL-6 levels.
Palabras clave
Texto completo:
1
Banco de datos:
LILACS
Asunto principal:
Schistosoma mansoni
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Interleucina-12
Límite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Jornal brasileiro de medicina tropical
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Rev Soc Bras Med Trop
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Rev. Soc. Bras. Med. Trop
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Rev. Soc. Bras. Med. Trop. (Online)
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Revista da Sociedade Brasileira de Medicina Tropical (Impresso)
Asunto de la revista:
MEDICINA TROPICAL
Año:
2021
Tipo del documento:
Article
País de afiliación:
Brasil