Chikungunya virus infection in the southernmost state of Brazil was characterised by self-limited transmission (2017-2019) and a larger 2021 outbreak
Gregianini, Tatiana Schäffer; Salvato, Richard Steiner; Barcellos, Regina Bones; Godinho, Fernanda Marques; Ruivo, Amanda Pellenz; de Melo, Viviane Horn; Schroder, Júlio Augusto; Martiny, Fernanda Letícia; Möllmann, Erica Bortoli; Favreto, Cátia; Baethgen, Ludmila Fiorenzano; Ferreira, Vithoria Pompermaier; de Lima, Lívia Eidt; Piazza, Cláudia Fasolo; Machado, Taís Raquel Marcon; Becker, Irina Marieta; Ramos, Raquel Rocha; Frölich, Guilherme Carey; Rossetti, Alana Fraga; Almeida, Lucas da Cunha; Rodrigues, Tahiana Machado Antunes; Bragança, Isabella Tabelli; Campos, Aline Alves Scarpellini; Manzoni, Verônica Baú; Machado, Lais Ceschini; da Silva, Luisa Maria Inácio; de Oliveira, André Luiz Sá; Paiva, Marcelo Henrique Santos; Nunes, Zenaida Marion Alves; de Almeida, Paula Rodrigues; Demoliner, Meriane; Gularte, Juliana Schons; da Silva, Mariana Soares; Filippi, Micheli; Pereira, Vyctoria Malayhka de Abreu Góes; Spilki, Fernando Rosado; da Veiga, Ana Beatriz Gorini; Wallau, Gabriel Luz.
Mem. Inst. Oswaldo Cruz
; 118: e220259, 2023. tab, graf
Artículo
en Inglés
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LILACS-Express
| ID: biblio-1448699
BACKGROUND Chikungunya is a mosquito-borne virus that has been causing large outbreaks in the Americas since 2014. In Brazil, Asian-Caribbean (AC) and East-Central-South-African (ECSA) genotypes have been detected and lead to large outbreaks in several Brazilian states. In Rio Grande do Sul (RS), the southernmost state of Brazil, the first cases were reported in 2016. OBJECTIVES AND METHODS We employed genome sequencing and epidemiological investigation to characterise the Chikungunya fever (CHIKF) burden in RS between 2017-2021. FINDINGS We detected an increasing CHIKF burden linked to travel associated introductions and communitary transmission of distinct lineages of the ECSA genotype during this period. MAIN CONCLUSIONS Until 2020, CHIKV introductions were most travel associated and transmission was limited. Then, in 2021, the largest outbreak occurred in the state associated with the introduction of a new ECSA lineage. CHIKV outbreaks are likely to occur in the near future due to abundant competent vectors and a susceptible population, exposing more than 11 million inhabitants to an increasing infection risk.
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