Vascular and ventilatory mechanical responses in three different stages of pulmonary development in the rabbit model of congenital diaphragmatic hernia
Figueira, Rebeca Lopes; Costa, Karina Miura da; Marsico, Ana Laura; Milani, Thamires Melchiades da Silva; Gonçalves, Walusa Assad; Borges, Marcos de Carvalho; Silva, Orlando Castro e; Sbragia, Lourenço.
Acta cir. bras
; 33(10): 879-888, Oct. 2018. graf
Artículo
en Inglés
| LILACS | ID: biblio-973464
Abstract
Purpose:
To evaluate the vascular ventilatory response in different stages of lung development and to compare them to the neonates with congenital diaphragmatic hernia (CDH) in a rabbit model.Methods:
New Zealand rabbits were divided into 8 groups (n=5) E25, E27, E30, and CDH. All groups were ventilated on a FlexiVent (Scireq, Montreal, QC, Canada), compounding the other 4 groups. The CDH surgery was performed at E25 and the harvest at E30. Dynamic compliance (CRS), dynamic elastance (ERS) and dynamic resistance (RRS) were measured every 4 min/24 min. Median wall thickness (MWT) and airspace were measured. ANOVA Bonferroni tests were used to perform statistical analysis. Significance was considered when p<0.05.Results:
CRS was higher in E30 compared to all other groups (p<0.05). CRS and RRS of CDH and E27 were similar and were higher in E25 (p<0.05). MWT was decreased according to the gestational age, was increased in E27V and E30V (p<0.05) and decreased in CDHV (p<0.05), airspace was decreased in E25 and increased in all ventilated groups (p<0.05).Conclusions:
The ventilation response of congenital diaphragmatic hernia is like the pseudoglandular stage of the lung development. These findings add information about the physiology of pulmonary ventilation in CDH.
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