Serological responses in sheep injected with plasmids encoding bovine herpesvirus 1 (BHV-1) gD glycoprotein
Arq. bras. med. vet. zootec
; 55(3): 256-261, jun. 2003. graf
Article
en En
| LILACS
| ID: lil-350602
Biblioteca responsable:
BR68.1
ABSTRACT
A genetic vaccine consisting of the bovine herpesvirus-1.2a (BHV-1.2a) glycoprotein D (gD) gene under the control of the cytomegalovirus immediate-early promoter/enhancer was generated and administered to sheep intramuscularly in the neck. All animals developed serum antibodies which recognized the homologous antigen (BHV-1.2a strain BH-83) and also exhibited cross-reactivity against the heterologous antigen (BHV-5 strain EVI-190). Three intramuscularly injections were given but serological responses were not improved after the second inoculation. Specific antibodies were detected against BHV-1.2a until at least 12 months after the first inoculation. However, the capacity to induce antibodies against BHV-5 was lower and of shorter duration than to BHV-1.2a.
Texto completo:
1
Banco de datos:
LILACS
Asunto principal:
Ensayo de Inmunoadsorción Enzimática
/
Herpesvirus Bovino 1
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Vacunas de ADN
Límite:
Animals
Idioma:
En
Revista:
Arq. bras. med. vet. zootec
Asunto de la revista:
MEDICINA VETERINARIA
Año:
2003
Tipo del documento:
Article
/
Project document
País de afiliación:
Brasil