The impact of glucocorticoids and anti-cd20 therapy on cervical human papillomavirus infection risk in women with systemic lupus erythematosus
Clinics
; 68(12): 1475-1480, dez. 2013. tab
Article
en En
| LILACS
| ID: lil-697701
Biblioteca responsable:
BR1.1
ABSTRACT
OBJECTIVE:
To identify the prevalence and factors associated with cervical human papillomavirus infection in women with systemic lupus erythematosusMETHODS:
This cross-sectional study collected traditional and systemic lupus erythematosus-related disease risk factors, including conventional and biologic therapies. A gynecological evaluation and cervical cytology screen were performed. Human papillomavirus detection and genotyping were undertaken by PCR and linear array assay.RESULTS:
A total of 148 patients were included, with a mean age and disease duration of 42.5±11.8 years and 9.7±5.3 years, respectively. The prevalence of squamous intraepithelial lesions was 6.8%. The prevalence of human papillomavirus infection was 29%, with human papillomavirus subtype 59 being the most frequent. Patients with human papillomavirus were younger than those without the infection (38.2±11.2 vs. 44.2±11.5 years, respectively; p = 0.05), and patients with the virus had higher daily prednisone doses (12.8±6.8 vs. 9.7±6.7 mg, respectively; p = 0.01) and cumulative glucocorticoid doses (14.2±9.8 vs. 9.7±7.3 g, respectively; p = 0.005) compared with patients without. Patients with human papillomavirus infection more frequently received rituximab than those without (20.9% vs. 8.5%, respectively; p = 0.03). In the multivariate analysis, only the cumulative glucocorticoid dose was associated with human papillomavirus infection.CONCLUSIONS:
The cumulative glucocorticoid dose may increase the risk of human papillomavirus infection. Although rituximab administration was more frequent in patients with human papillomavirus infection, no association was found. Screening for human papillomavirus infection is recommended in women with systemic lupus erythematosus. .Palabras clave
Texto completo:
1
Banco de datos:
LILACS
Asunto principal:
Enfermedades del Cuello del Útero
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Infecciones por Papillomavirus
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Anticuerpos Monoclonales de Origen Murino
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Glucocorticoides
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Factores Inmunológicos
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Lupus Eritematoso Sistémico
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Female
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Humans
País/Región como asunto:
Mexico
Idioma:
En
Revista:
Clinics
Asunto de la revista:
MEDICINA
Año:
2013
Tipo del documento:
Article
País de afiliación:
México