Prenatal management, pregnancy and pediatric outcomes in fetuses with septated cystic hygroma
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;47(9): 799-803, 09/2014. tab, graf
Article
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| LILACS
| ID: lil-719319
Biblioteca responsable:
BR1.1
ABSTRACT
It has been reported that, compared with simple increased nuchal translucency, fetal cases with septated cystic hygroma (CH) are more likely to face perinatal handicaps. However, pediatric outcomes and proper prenatal counseling for this anomaly have not yet been truly defined. We performed this study to determine pregnancy and pediatric outcomes of fetuses with septated CH. We searched records for cases with septated CH and collected data for structural abnormalities, karyotype analysis, and pregnancy outcomes. Fetuses born with septated CH were also evaluated for their pediatric outcomes. Sixty-nine fetuses with septated CH were enrolled in the study. Results showed that chromosomal abnormalities were present in 28 fetuses (40.6%), and the most common aneuploidy was Turner syndrome (n=14, 20.3%); 16 (23.2%) of the remaining cases, in which aneuploidy was not found, had coexistent structural malformations; 25 (36.2%) cases had normal karyotype and morphology. The total number of live births and infants with unfavorable neurologic follow-up were 13 (18.8%) and 2 (2.9%), respectively. Septated CH is associated with poor perinatal outcomes; therefore, karyotype analysis and ultrasonographic anomaly screening should be performed as initial steps, and expectant management should be offered to couples with euploid fetuses that have normal morphology.
Palabras clave
Texto completo:
1
Banco de datos:
LILACS
Asunto principal:
Hidropesía Fetal
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Aberraciones Cromosómicas
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Linfangioma Quístico
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Female
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Humans
/
Pregnancy
País/Región como asunto:
Asia
Idioma:
En
Revista:
Braz J Med Biol Res
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Braz. j. med. biol. res
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Braz. j. med. biol. res. (Online)
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Brazilian journal of medical and biological research
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Brazilian journal of medical and biological research (Impresso)
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Rev. bras. pesqui. méd. biol
/
Revista brasileira de pesquisas médicas e biológicas
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Turquía