Protective effect of hydrogen sulfide on renal injury in the experimental unilateral ureteral obstruction
Int. braz. j. urol
; 41(6): 1185-1193, Nov.-Dec. 2015. tab, graf
Article
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| LILACS
| ID: lil-769773
Biblioteca responsable:
BR1.1
ABSTRACT
Introduction/Objective:
Ureteral obstruction is a common pathology and causes kidney fibrosis and dysfunction at late period. In this present study, we investigated the antifibrotic and antiinflammatory effects of hydrogen sulfide on kidney damage after unilateral ureteral obstruction (UUO) in rats. Materials andMethods:
24 rats were divided into four groups. Group 1 was control, group 2 was sham, group 3 included rats with UUO and group 4 rats with UUO which were given sodium hydrogen sulfide (NaHS)-exogenous donor of hydrogen sulfide (intraperitoneally 56μmoL/kg/day). After 14 days, rats were killed and their kidneys were taken and blood analysis was performed. Tubular necrosis, mononuclear cell infiltration and interstitial fibrosis were determined histopathologically in a part of the kidneys; nitric oxide (NO), malondialdehyde (MDA) and reduced glutathione (GSH) levels were determined in the other part of the kidneys. Urea-creatinine levels were investigated by blood analysis. Statistical analyses were made by the Chi-square test and one-way analysis of variance (ANOVA).Results:
There was no significantly difference for urea-creatinine levels among groups. Pathologically, there was serious tubular necrosis and fibrosis in group 3 and there was significantly decreasing of tubular necrosis and fibrosis in group 4 (p<0.005). Also, there was significantly increase of NO and MDA levels and decrease of GSH levels in group 3 compared to other groups (p<0.005).Conclusions:
hydrogen sulfide prevents kidney damage with antioxidant and antiinflammatory effect.Palabras clave
Texto completo:
1
Banco de datos:
LILACS
Asunto principal:
Obstrucción Ureteral
/
Insuficiencia Renal
/
Sulfuro de Hidrógeno
/
Antiinflamatorios
Tipo de estudio:
Etiology_studies
/
Evaluation_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Int. braz. j. urol
Asunto de la revista:
UROLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Turquía