Relationship between major depressive disorder and ACE gene I/D polymorphism in a Turkish population
Arch. Clin. Psychiatry (Impr.)
; 43(2): 27-30, Mar.-Apr. 2016. tab, ilus
Article
en En
| LILACS
| ID: lil-782109
Biblioteca responsable:
BR1.1
ABSTRACT
Abstract Background Major depressive disorder (MDD) is a complex disease and a significant health problem that is prevalent across the world. Angiotensin-converting enzyme (ACE) has an important role in renin-angiotensin system (RAS) and converts inactive angiotensin I to a potent vasopressor and aldosterone-stimulating peptide angiotensin II. Levels of ACE in plasma vary according to the insertion/deletion (I/D) polymorphism of ACE gene. Objective The aim of the current study was to examine the influence ACE gene I/D variations on the risk of MDD. Methods In the present case-control study, we analyzed ACE I/D polymorphism in 346 MDD patients and 210 healthy subjects using polymerase chain reaction technique. Results Comparing the two groups, no significant difference was observed with regard to either genotype distributions or allele frequencies of the I/D polymorphism of ACE gene. Discussion Our findings suggest that the ACE I/D polymorphism is not associated with MDD in Turkish case-control study. Further studies are still needed.
Palabras clave
Texto completo:
1
Banco de datos:
LILACS
Asunto principal:
Polimorfismo Genético
/
Población
/
Depresión
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Arch. Clin. Psychiatry (Impr.)
Asunto de la revista:
PSIQUIATRIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Turquía