Suggested that groups treated with L-arginine orally or topically improved wound repair when compared with non-treatad mice. L- argininetreatment stimulated TGF-β and restricted NO production leading to a mild Th1 response and collagen deposition in injured area, when it was orally administrated. Topical administration decreased IL-8 and CCR1 expression by woundcells but did not interfere with TNF-α and IL-10production, ratifying the decrease of inflammatory response, the oral administration however, presented a higher iNOS and TGF-β expression then. L-argininetreatment also improved the improved the wound healing in immunosupressed or diabetic mice.
CONCLUSION:
L-arginine administrated orally or topically can be considered an important factor in the recuperation of tissues.