Genetic variants in the tumor necrosis factor receptor 1 gene in patients with MS.
Neurology
; 52(7): 1500-3, 1999 Apr 22.
Article
en En
| MEDLINE
| ID: mdl-10227645
ABSTRACT
We scanned for all genetic variants in functionally important regions of the tumor necrosis factor receptor 1 gene (TNF-R1) in 100 to 111 MS patients from Olmsted County, MN, and analyzed selected variants for an association with disease course and severity. Ten genetic variants were uncovered. Only one variant, a silent substitution, was found in coding sequence. One intronic variant may generate a novel splice-junction sequence. We did not find an association between either this intronic variant or another common promoter variant and the course or severity of MS.
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Banco de datos:
MEDLINE
Asunto principal:
Variación Genética
/
Receptores del Factor de Necrosis Tumoral
/
Esclerosis Múltiple
Límite:
Humans
Idioma:
En
Revista:
Neurology
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos