Diagnostic value of anti-alpha FP antibody levels in a metastatic germ cell tumor of unknown primary site.
Anticancer Res
; 19(3B): 2201-4, 1999.
Article
en En
| MEDLINE
| ID: mdl-10472331
ABSTRACT
BACKGROUND:
A 21 year old man with a metastatic germ cell tumor of unknown primary not responding to chemotherapy was scheduled to have a blind bilateral orchiectomy to eradicate the possible primary site although palpation and ultrasonography of the testicles had always been normal.METHOD:
The patient underwent a radioimmunoscintigraphy with Anti-alpha FP antibody scan (AFP-Scan).RESULTS:
On the basis of the scintigraphic results the patient underwent a left orchiectomy and additionally removal of the lymph node metastases. Histology revealed the presence of an in situ carcinoma in the left testis and a mixed tumor present in the abdominal lymph node metastases. Fluorescent in situ hybridization on tumor cells did not show any abnormalities related to chromosome 12, a finding connected with the somatic type of germ cell tumors.CONCLUSION:
Anti-alpha FP antibody scan was helpful in detecting the primary site and saving the life of the patient without resulting in hypogonadism.
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Banco de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
/
Neoplasias Primarias Desconocidas
/
Alfa-Fetoproteínas
/
Germinoma
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Anticancer Res
Año:
1999
Tipo del documento:
Article
País de afiliación:
Grecia