Identification of a novel amplicon at 1q31 in pancreatic cancer cell lines.
Cancer Genet Cytogenet
; 113(2): 110-4, 1999 Sep.
Article
en En
| MEDLINE
| ID: mdl-10484975
ABSTRACT
Pancreatic adenocarcinoma is a highly lethal malignant tumor that is increasing in frequency, now ranking fifth in the United States as a cause of death attributed to cancer. Patients with pancreatic carcinoma have one of the poorest prognoses of all cancer patients, with the number of deaths being approximately 75% of the total number of cases. The use of comparative genomic hybridization (CGH) has gained widespread use in the study of some types of solid tumors, and it seems to be a very good approach in pancreatic adenocarcinomas, in which just a few cases have been studied cytogenetically, mostly owing to the fact that these tumors are very difficult to grow in culture. Fourteen pancreatic cancer lines were examined with CGH. In 11 of these lines, we found an amplicon at 1q31, not previously reported in pancreatic cancer. More studies need to be done in primary tumors to determine the involvement of 1q31 in this type of tumor.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Pancreáticas
/
Cromosomas Humanos Par 1
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Cancer Genet Cytogenet
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos