Frequent loss of imprinting of PEG1/MEST in invasive breast cancer.
Cancer Res
; 59(21): 5449-51, 1999 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-10554015
ABSTRACT
The human PEG1 gene is a newly identified imprinted gene on 7q32. Genetic aberrations of this chromosomal region are often detected in invasive breast carcinomas. In this study, we show monoallelic PEG1 expression in normal breast tissue, indicating the presence of a functional imprint, and more importantly, we demonstrate loss of imprinting (LOI) in all of seven informative invasive breast carcinomas. In contrast to this, in one case of atypical ductal hyperplasia (ADH) found in residual breast, imprinting was maintained. This raises the possibility that aberrant imprinting of PEG1 may be involved in the progression from hyperplasia to invasive breast cancer.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Proteínas
/
Impresión Genómica
Tipo de estudio:
Risk_factors_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Cancer Res
Año:
1999
Tipo del documento:
Article
País de afiliación:
Irlanda