End-stage renal disease in two pediatric patients with Fechtner syndrome.
Pediatr Nephrol
; 13(9): 782-6, 1999 Nov.
Article
en En
| MEDLINE
| ID: mdl-10603121
ABSTRACT
Fechtner syndrome, a disease in the spectrum of the hereditary nephridites, is a macrothrombocytopenia associated with sensorineural hearing loss, cataracts, nephritis, and characteristic leukocyte inclusions. Renal biopsy findings are consistent with those of Alport syndrome, and the associated renal disease is said to be unusual before mid to late adulthood. Here, we review the available literature on this disease and report two African-American pediatric patients with Fechtner syndrome who rapidly progressed to end-stage renal disease during adolescence. We conclude that chronic renal failure can occur at a young age in patients with Fechtner syndrome, with a possible relation to race/ethnicity. Fechtner syndrome, or other variants of Alport syndrome, need to be considered in patients presenting with proteinuria and thrombocytopenia.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Trombocitopenia
/
Fallo Renal Crónico
/
Nefritis Hereditaria
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Pediatr Nephrol
Asunto de la revista:
NEFROLOGIA
/
PEDIATRIA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos