Preclinical mouse models for cancer chemoprevention studies.
Ann N Y Acad Sci
; 889: 14-9, 1999.
Article
en En
| MEDLINE
| ID: mdl-10668478
ABSTRACT
To aid in identifying the ability of chemopreventive agents to inhibit tumor development, new preclinical in vivo rodent models have recently been developed. Some of the models contain targeted mutations capable of increasing the incidence and progression of neoplastic lesions, whereas in other models dietary nutrients induce preneoplastic lesions in normal mice. These new preclinical models are assisting the analysis of genetic and environmental factors leading to neoplasia, and clinical studies to evaluate the chemopreventive efficacy of specific nutrients and pharmacological agents.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Modelos Animales de Enfermedad
/
Neoplasias Experimentales
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Ann N Y Acad Sci
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos