P-glycoprotein is localized in caveolae in resistant cells and in brain capillaries.
FEBS Lett
; 466(2-3): 219-24, 2000 Jan 28.
Article
en En
| MEDLINE
| ID: mdl-10682831
ABSTRACT
A significant proportion of P-glycoprotein (P-gp) and caveolin was co-localized in caveolae isolated from resistant (CH(R)C5) cells overexpressing P-gp and from drug-sensitive Chinese hamster ovary cells (AuxB1). The proportion of P-gp and caveolin associated with caveolar microdomains was higher in CH(R)C5 cells grown in the presence of P-gp substrates (cyclosporin A or colchicine) than in untreated CH(R)C5 cells. Coimmunoprecipitation of P-gp and caveolin from CH(R)C5 lysates suggests that there is a physical interaction between them. Furthermore, co-localization of P-gp and caveolin was found in caveolae from brain capillaries, indicating that this association also takes place in vivo.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Capilares
/
Miembro 1 de la Subfamilia B de Casetes de Unión a ATP
Límite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2000
Tipo del documento:
Article
País de afiliación:
Canadá