Fast potentiation of glycine receptor channels of intracellular calcium in neurons and transfected cells.
Neuron
; 28(2): 571-83, 2000 Nov.
Article
en En
| MEDLINE
| ID: mdl-11144365
ABSTRACT
Inhibitory glycine receptors (GlyRs) are mainly expressed in the spinal cord and in the midbrain, where they control motor and sensory pathways. We describe here a fast potentiation of GlyR by intracellular Ca2+. This phenomenon was observed in rat spinal cord neurons and in transfected human cell lines. Potentiation develops in <100 ms, is proportional to Ca2+ influx, and is characterized by an increase in GlyR apparent affinity for glycine. Phosphorylation and G protein pathways appear not to be involved in the potentiation mechanism. Single-channel recordings in cell-attached and excised patches, as well as whole-cell data suggest the presence of a diffusible cytoplasmic factor that modulates the GlyR channel gating properties. Ca2+-induced potentiation may be important for rapid modulation of glycinergic synapses.
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Banco de datos:
MEDLINE
Asunto principal:
Calcio
/
Ácido Egtácico
/
Receptores de Glicina
/
Líquido Intracelular
/
Neuronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Neuron
Asunto de la revista:
NEUROLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Francia