Potent integrin antagonists from a small library of RGD-including cyclic pseudopeptides.
Org Lett
; 3(7): 1001-4, 2001 Apr 05.
Article
en En
| MEDLINE
| ID: mdl-11277780
[structure: see text]. A small library of cyclic RGD pseudopentapeptides incorporating stereoisomeric 6,5- and 7,5-fused bicyclic lactams was synthesized with the aim of developing active and selective integrin antagonists. The solid-phase synthesis and activity of these RGD derivatives is described. The approach led to two of the most active known inhibitors of alpha(V)beta3 receptor.
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Banco de datos:
MEDLINE
Asunto principal:
Oligopéptidos
/
Compuestos Bicíclicos con Puentes
/
Receptores de Vitronectina
/
Lactamas
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Italia