Alterations in signal transduction cascade in young and adult rat brain and lymphocytes.
Brain Res Bull
; 54(5): 513-20, 2001 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-11397541
ABSTRACT
Signal transduction cascade, phosphoinositide metabolism, and protein kinases were studied from discrete areas of rat brain like cerebral hemispheres, cerebellum, brainstem, and diencephalon as well as lymphocytes isolated from three different age groups of rats; young (1 month), young adult (3-4 months), and adult (12 months) rats. The activities of protein kinase A, protein kinase C, phospholipase A(2) and phospholipase C and inositol 1, 4, 5-triphosphate, diacylglycerol, cyclic adenosine monophosphate contents were assayed from different brain areas and lymphocytes from these three age group rats. An upregulatory effect on the signal transduction system was observed from 1 month to 3-4-month age group, whereas, the brain tissue and lymphocytes of adult rats showed lower contents and activities of signal transduction components as compared to young adults. In view of the established 'cross talk' between signal transduction system, the present results suggests that molecular/cellular changes in brain and immune cells signal transduction pathway along with neuronal cell loss may contribute to age-related decline in nervous as well as immune system functions.
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Banco de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Química Encefálica
/
Linfocitos
/
Sistemas de Mensajero Secundario
/
Transducción de Señal
/
Sistema Inmunológico
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Brain Res Bull
Año:
2001
Tipo del documento:
Article
País de afiliación:
India