A case of familial Mediterranean fever with amyloidosis as the first manifestation.
Am J Kidney Dis
; 38(6): E34, 2001 Dec.
Article
en En
| MEDLINE
| ID: mdl-11728994
ABSTRACT
We describe a 22-year-old Turkish woman with nephrotic syndrome who had a history of acute myelocytic leukemia. After careful clinical evaluation, the patient underwent a renal biopsy. Light microscopic examination showed deposition of Congo-positive material both in the mesangium and around the small vessels. By histochemical analyses, the deposited material was proved to be amyloid A (AA). Because the patient's history did not reveal any event that might explain the development of secondary amyloidosis, she was screened for mutations causing familial Mediterranean fever (FMF) and was found to be homozygous for the M694V mutation by denaturing gradient gel electrophoresis. We recommend that FMF-Phenotype II and the development of amyloid nephropathy, before or without other symptoms of FMF, should be kept in mind in the face of unexplained proteinuria/amyloidosis, especially in high-risk ethnic groups.
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Banco de datos:
MEDLINE
Asunto principal:
Fiebre Mediterránea Familiar
/
Amiloidosis
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Am J Kidney Dis
Año:
2001
Tipo del documento:
Article
País de afiliación:
Turquía