[Apoptosis as a measure of chemosensitivity to anti-cancer drugs in gynecological cancer].
Gan To Kagaku Ryoho
; 29(2): 215-9, 2002 Feb.
Article
en Ja
| MEDLINE
| ID: mdl-11865626
ABSTRACT
OBJECTIVE:
To examine apoptosis as a measure of chemosensitivity to anti-cancer drugs in gynecological cancer xenografted into nude mice.METHODS:
The TUNEL method was used to investigate the induction of apoptosis after exposure to anti-cancer drugs in thirteen gynecological cancers xenografted into nude mice. Moreover, in vivo sensitivities of gynecologic cancer to anti-cancer drugs were determined according to the protocol developed by Battle Laboratories, Columbus, Ohio USA. Both methods were examined for correlation.RESULTS:
The apoptosis index by the TUNEL method showed a correlation with the findings using the protocol developed by Battle Laboratories, Columbus, Ohio USA.CONCLUSIONS:
Our findings indicate the ability to determine the measure of chemosensitivity by the apoptosis index.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
/
Camptotecina
/
Cisplatino
/
Apoptosis
/
Antineoplásicos
Límite:
Animals
/
Female
/
Humans
Idioma:
Ja
Revista:
Gan To Kagaku Ryoho
Año:
2002
Tipo del documento:
Article