Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice.
Circulation
; 106(4): 484-90, 2002 Jul 23.
Article
en En
| MEDLINE
| ID: mdl-12135950
ABSTRACT
BACKGROUND:
Serum paraoxonase (PON1), an enzyme carried on HDL, inhibits LDL oxidation, and in human population studies, low PON1 activity is associated with atherosclerosis. In addition, PON1 knockout mice are more susceptible to lipoprotein oxidation and atherosclerosis. To evaluate whether PON1 protects against atherosclerosis and lipid oxidation in a dose-dependent manner, we generated and studied human PON1 transgenic mice. METHODS ANDRESULTS:
Human PON1 transgenic mice were produced by using bacterial artificial chromosome genomic clones. The mice had 2- to 4-fold increased plasma PON1 levels, but plasma cholesterol levels were unchanged. Atherosclerotic lesions were significantly reduced in the transgenic mice when both dietary and apoE-null mouse models were used. HDL isolated from the transgenic mice also protected against LDL oxidation more effectively.CONCLUSIONS:
Our results indicate that PON1 protects against atherosclerosis in a dose-dependent manner and suggest that it may be a potential target for developing therapeutic agents for the treatment of cardiovascular disease.
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Banco de datos:
MEDLINE
Asunto principal:
Arteriosclerosis
/
Esterasas
/
Antioxidantes
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Circulation
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos