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A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead.
Wilanowski, Tomasz; Tuckfield, Annabel; Cerruti, Loretta; O'Connell, Sinead; Saint, Robert; Parekh, Vishwas; Tao, Jianning; Cunningham, John M; Jane, Stephen M.
Afiliación
  • Wilanowski T; Rotary Bone Marrow Research Laboratory, Royal Melbourne Hospital Research Foundation, c/o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria 3050, Australia.
Mech Dev ; 114(1-2): 37-50, 2002 Jun.
Article en En | MEDLINE | ID: mdl-12175488
The Drosophila transcription factor Grainyhead regulates several key developmental processes. Three mammalian genes, CP2, LBP-1a and LBP-9 have been previously identified as homologues of grainyhead. We now report the cloning of two new mammalian genes (Mammalian grainyhead (MGR) and Brother-of-MGR (BOM)) and one new Drosophila gene (dCP2) that rewrite the phylogeny of this family. We demonstrate that MGR and BOM are more closely related to grh, whereas CP2, LBP-1a and LBP-9 are descendants of the dCP2 gene. MGR shares the greatest sequence homology with grh, is expressed in tissue-restricted patterns more comparable to grh and binds to and transactivates the promoter of the human Engrailed-1 gene, the mammalian homologue of the key grainyhead target gene, engrailed. This sequence and functional conservation indicates that the new mammalian members of this family play important developmental roles.
Asunto(s)
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Banco de datos: MEDLINE Asunto principal: Proteínas Represoras / Factores de Transcripción / Proteínas de Unión al ADN Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Mech Dev Asunto de la revista: EMBRIOLOGIA Año: 2002 Tipo del documento: Article País de afiliación: Australia
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Banco de datos: MEDLINE Asunto principal: Proteínas Represoras / Factores de Transcripción / Proteínas de Unión al ADN Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Mech Dev Asunto de la revista: EMBRIOLOGIA Año: 2002 Tipo del documento: Article País de afiliación: Australia