Your browser doesn't support javascript.
loading
Endogenous interleukin-12 is critical for controlling the late but not the early stage of Leishmania mexicana infection in C57BL/6 mice.
Aguilar Torrentera, Fabiola; Laman, Jon D; Van Meurs, Marjan; Adorini, Luciano; Muraille, Eric; Carlier, Y.
Afiliación
  • Aguilar Torrentera F; Laboratory of Parasitology, Free University of Brussels (ULB), Brussels, Belgium.
Infect Immun ; 70(9): 5075-80, 2002 Sep.
Article en En | MEDLINE | ID: mdl-12183555
ABSTRACT
The role of interleukin-12 (IL-12) has been clearly established in the resistance of C57BL/6 (B6) mice to Leishmania major infection, but its involvement in the control of Leishmania mexicana infection remains to be determined. Here, we show the following. (i) L. mexicana, in contrast to L. major, induces the development of nonhealing lesions in B6 mice. (ii) Cells expressing IL-12p40, gamma interferon (IFN-gamma), NOS2, and CD40L are numerous in the footpad lesion and/or the draining popliteal lymph node of animals infected for up to 14 weeks with L. mexicana. (iii) B6 mice, either IL-12p40 deficient or treated with IL-12p40-neutralizing antibodies, display a dramatic enhancement of primary and secondary lesions leading to death 10 weeks after inoculation with L. mexicana. (iv) Splenocytes harvested 4 and 8 weeks after infection of IL-12p40(-/-) B6 mice with L. mexicana are unable to produce IFN-gamma, but secrete IL-4, IL-10, and IL-18. Thus, the early control of L. mexicana infection by B6 mice is independent of IL-12, whereas IL-12 and Th1 responses play a key role in controlling the late stages of L. mexicana infection. However, they fail to resolve lesions, in contrast to L. major infection, emphasizing the different outcomes induced by these two Leishmania species in B6 mice.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leishmania mexicana / Leishmaniasis Cutánea / Interleucina-12 Límite: Animals País/Región como asunto: Mexico Idioma: En Revista: Infect Immun Año: 2002 Tipo del documento: Article País de afiliación: Bélgica

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leishmania mexicana / Leishmaniasis Cutánea / Interleucina-12 Límite: Animals País/Región como asunto: Mexico Idioma: En Revista: Infect Immun Año: 2002 Tipo del documento: Article País de afiliación: Bélgica