[Experimental study on effect of sanmiao mixture capsules on prostate hyperplasia in mice and rats].

ABSTRACT

OBJECTIVE: To observe the effect of Sanmiao Mixture Capsules(SMC) on prostate hyperplasia in mice and rats. METHOD: The model of prostate hyperplasia was made by injecting testosterone propionate in to male mice(5 g.kg-1.d-1, 21 d) and rats(3 g.kg-1.d-1, 14 d). The treated group was administered SMC(mice 36.3 g.kg-1 and 18.2 g.kg-1; rats 25.2 g.kg-1 and 12.6 g.kg-1), the normal control group 1.9 g.kg-1, and the model control group NS. hours after the last administration serum tests were carried out on E2, AKP and Zn2+. Then the animals were killed, prostates taken out and weighed, index of prostate was calculated and pathological examination performed. RESULT: In the SMC treated group, the prostate weight and index were lowered(P < 0.01) the mean activation of E2 was raised, and the mean concentration of AKP and Zn2+ was inhibited (P < 0.01). CONCLUSION: SMC are helpful in checking prostate hyperplasia in mice and rats, the mechanism being probably related to the raising of activation of E2 as well as to the inhibition of concentration of AKP and Zn2+.