The Framingham prediction rule is not valid in a European population of treated hypertensive patients.
J Hypertens
; 20(10): 1973-80, 2002 Oct.
Article
en En
| MEDLINE
| ID: mdl-12359975
ABSTRACT
BACKGROUND:
Stratification of population groups according to cardiovascular risk level is recommended for primary prevention.OBJECTIVE:
To assess whether the Framingham models could accurately predict the absolute risk of coronary heart disease (CHD) and stroke in a large cohort of middle-aged European patients with hypertension, and rank individual patients according to actual risk.DESIGN:
A prospective cohort study comparing the actual risk with that predicted by either the Framingham equations or models derived from the INSIGHT study. PATIENTS ANDSETTING:
From the INSIGHT prospective trial, conducted in eight countries of Western Europe and Israel, we selected 4407 European patients younger than 75 years without previous cardiovascular events.INTERVENTIONS:
None. MAIN OUTCOMEMEASURES:
Major cardiovascular events.RESULTS:
In this population (45% men, mean age 64.1 years), 124 (2.8%) patients had CHD and 96 (2.2%) had strokes after a median follow-up of 3.7 years. Overestimation of absolute CHD risk by the Framingham equation was observed in all countries (from 2% in the UK to 7% in France), whereas predicted risk of stroke was close to the actual risk. However, patients in the highest risk quintile within each country had a threefold greater risk of a cardiovascular event than those in the lowest quintile.CONCLUSIONS:
The Framingham models should not be used to predict absolute CHD risk in the European population as a whole. However, these models may be used within each country, provided that cut-off points defining high-risk patients have been determined within each country.
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Banco de datos:
MEDLINE
Asunto principal:
Hipertensión
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Evaluation_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Asia
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Europa
Idioma:
En
Revista:
J Hypertens
Año:
2002
Tipo del documento:
Article
País de afiliación:
Francia