The control of bone growth by parathyroid hormone, leptin, & statins.
Crit Rev Eukaryot Gene Expr
; 12(1): 23-51, 2002.
Article
en En
| MEDLINE
| ID: mdl-12433064
ABSTRACT
There is a need for anabolic drugs that can stimulate bone growth, improve bone microarchitecture, accelerate fracture healing and thus restore bone strength to oteoporotics. The anabolic agents currently leading the way to the clinic are the parathroid hormone (PTH) and some of its adenylyl cyclase-stimulating fragments. Here we discuss what is known about the genes and their products that are stimulated by PTHR1 receptor signals and in four ways cause a large accumulation of bone-building osteoblasts. We will also discuss the currently controversial anabolic activity of the cholesterol-lowering statins and outline a possible mechanism by which they might stimulate BMP-2 expession and bone growth. Finally, we will present the growing evidence for the body's "fat-o-stat" cytokine-leptin-indirectly restraining bone growth via a hypothalamic factor and at the same serving as a local autocrine/paracrine stimulator of osteoblast activity via IGF-I and an inhibitor of osteoclast generation by stimulating osteoblastic cells' antiosteoclast OPG (osteoprotegerin) expression and reducing their proosteoclast RANKL expression.
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Banco de datos:
MEDLINE
Asunto principal:
Hormona Paratiroidea
/
Desarrollo Óseo
/
Inhibidores de Hidroximetilglutaril-CoA Reductasas
/
Leptina
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Crit Rev Eukaryot Gene Expr
Asunto de la revista:
BIOLOGIA MOLECULAR
/
BIOTECNOLOGIA
Año:
2002
Tipo del documento:
Article